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Dexmedetomidine hydrochloride

Catalog #: 2749
7 Citations Datasheet / COA / SDS
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2749/10
2749/50
Dexmedetomidine hydrochloride | CAS No. 145108-58-3 | Adrenergic alpha-2 Receptor Agonists
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Description: Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
Alternative Names: d-Medetomidine hydrochloride

Chemical Name: 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride

Purity: ≥98%

Product Details
Citations (7)
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Biological Activity

Dexmedetomidine hydrochloride is an active isomer of medetomidine, a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than Clonidine (Cat. No. 0690) and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Racemate also available.

Technical Data

M.Wt:
236.74
Formula:
C13H16N2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
145108-58-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist.
    Virtanen et al.
    Eur.J.Pharmacol., 1988;150:9
  2. Antinociceptive properties of intrathecal dexmedetom. in rats.
    Fisher et al.
    Eur.J.Pharmacol., 1991;192:221
  3. Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects.
    Scheinin et al.
    Prog.Neuro-Psychopharm.Biol.Psychiat., 1989;13:635

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Citations for Dexmedetomidine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Dexmedetomidine hydrochloride include:

7 Citations: Showing 1 - 7

  1. Induction of Non-Apoptotic Cell Death by Adrenergic Agonists in Human Oral Squamous Cell Carcinoma Cell Lines.
    Authors: Uchida Et al.
    Anticancer Res  2019;39:3519
  2. Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation
    Authors: Ma Et al.
    Curr Biol  2019;29:3315
  3. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552
  4. Corneal Anesthesia With Site 1 Sodium Channel Blockers and dexmedetom.
    Authors: McAlvin Et al.
    J Inflamm (Lond)  2015;56:3820
  5. Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat.
    Authors: Garrity Et al.
    Invest Ophthalmol Vis Sci  2015;38:73
  6. Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine.
    Authors: Gozzi Et al.
    Neuropsychopharmacology  2013;38:2120
  7. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function.
    Authors: Yuki Et al.
    Anesth Analg  2011;112:830

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