DG 041
Chemical Name: (2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide
Purity: ≥98%
Biological Activity
DG 041 is a potent and selective EP3 antagonist (IC50 = 4.6 nM). Inhibits PGE2 facilitation of platelet aggregation in vitro and ex vivo. Displays good plasma and metabolic stability. Does not affect bleeding time in rats. Antiplatelet and antithrombotic.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structural features of subtype-selective EP receptor modulators.
Markovič et al.
Drug Discov.Today., 2017;22:57 -
Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding.
Singh et al.
ACS Chem.Biol., 2009;4:115
Product Datasheets
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Citation for DG 041
The citations listed below are publications that use Tocris products. Selected citations for DG 041 include:
1 Citation: Showing 1 - 1
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Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells.
Authors: Dieter Et al.
Oncotarget 2016;7:32462-77
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