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(±)-Clopidogrel hydrochloride

Catalog #: 2490 Datasheet / COA / SDS
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2490/10
2490/50
(±)-Clopidogrel hydrochloride | CAS No. 130209-90-4 | P2Y Receptor Antagonists
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Description: Selective P2Y12 antagonist
Alternative Names: Plavix

Chemical Name: Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrochloride

Purity: ≥99%

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Biological Activity

(±)-Clopidogrel hydrochloride is a selective, high affinity P2Y12 receptor antagonist (pKi = 6.9 for hP2Y12 receptor). Inhibits ADP-induced platelet aggregation; potent antithrombotic agent. Requires bioactivation, unlike PSB 0739.

Active Enantiomer also available.

Technical Data

M.Wt:
358.28
Formula:
C16H16NO2SCl.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
130209-90-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.
    Kugelgen
    Pharmacol.Ther., 2006;110:415
  2. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis.
    Savi and Herbert
    Semin.Thromb.Haemostas., 2005;31:174
  3. P2Y12, a new platelet ADP receptor, target of clopid.
    Savi et al.
    Biochem.Biophys.Res.Comm., 2001;283:379

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