DMXAA
Chemical Name: 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid
Purity: ≥99%
Biological Activity
DMXAA is a mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity.
Corrales et al.
Cell Rep., 2015;11:1018 -
Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development.
Phillips
Biochem.Pharmacol., 1999;58:303 -
The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo.
Shirey et al.
J.Leukoc.Biol., 2011;89:351
Product Datasheets
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Citations for DMXAA
The citations listed below are publications that use Tocris products. Selected citations for DMXAA include:
2 Citations: Showing 1 - 2
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STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.
Authors: Bryon D Et al.
Cell Mol Gastroenterol Hepatol 2021;12:41-58
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Protocols for Experimental Sjögren's Syndrome.
Authors: Umesh S Et al.
Curr Protoc Immunol 2020;131:e114
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