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Dobutamine hydrochloride

Catalog #: 0515
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0515/50
Dobutamine hydrochloride | CAS No. 49745-95-1 | Non-selective Adrenergic beta Receptor Agonists
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Description: α1, β1 and β2 agonist

Chemical Name: 4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]aminoethyl-1,2-benzenediol hydrochloride

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Dobutamine hydrochloride is a β1- and β2-adrenoceptor agonist with some action at the α1-adrenoceptor.

Technical Data

M.Wt:
337.85
Formula:
C18H23NO3.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
49745-95-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pericytes impair capillary blood flow and motor function after chronic spinal cord injury
    Y Li, AM Lucas-Osma, S Black, MV Bandet, MJ Stephens, R Vavrek, L Sanelli, KK Fenrich, AF Di Narzo, S Dracheva, IR Winship, K Fouad, DJ Bennett
    Nat. Med., 2017;0(0):.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. Dobutamine: positive inotropy by nonselective adrenoceptor agonism in isolated guinea pig and human myocardium.
    Brown et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1987;335:385
  4. Characterization of the beta adrenoceptor subtype(s) mediating the positive inotropic effects of epinine, DA, dobutamine, denopamine and xamoterol in isolated human right atrium.
    Deighton et al.
    J.Pharmacol.Exp.Ther., 1992;262:532

Product Datasheets

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Citations for Dobutamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Dobutamine hydrochloride include:

3 Citations: Showing 1 - 3

  1. Pericytes impair capillary blood flow and motor function after chronic spinal cord injury.
    Authors: Li Et al.
    Nat Med  2017;23:733
  2. Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation.
    Authors: Kaya Et al.
    Biol Reprod  2009;329:350
  3. Pharmacological characterization of the receptors involved in the beta-adrenoceptor-mediated stimulation of the L-type Ca2+ current in frog ventricular myocytes.
    Authors: Skeberdis Et al.
    Br J Pharmacol  1997;121:1277

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