Doxazosin mesylate

Catalog #: 2964
4 Citations Datasheet / COA / SDS

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2964/50

Doxazosin mesylate | CAS No. 77883-43-3 | Adrenergic alpha-1 Receptor Antagonists

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Description: α1 antagonist

Alternative Names: UK 33274

Chemical Name: 4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate

Purity: ≥99%

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Product Details

Citations (4)

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Biological Activity

Doxazosin mesylate is a selective α₁-adrenoceptor antagonist (pK_i values are 9.0, 8.5 and 8.4 for human α_1B, α_1A and α_1D receptors respectively). Displays antihypertensive activity.

Technical Data

M.Wt:

547.58

Formula:

C₂₃H₂₅N₅O₅.CH₃SO₃H

Solubility:

Soluble to 75 mM in DMSO

Purity:

≥99%

Storage:

Desiccate at RT

CAS No:

77883-43-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The α₁-adrenoceptor antagonist profile of doxazosin: preclinical pharmacology.
Alabaster and Davey
Br.J.Clin.Pharmacol., 1986;21:9S
Evaluation of the pharmacological selectivity profile of α₁ adrenoceptor antagonists at prostatic α₁ adrenoceptors: binding functional and in vivo studies.
Kenny et al.
Br.J.Pharmacol., 1996;118:871

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Doxazosin mesylate

The citations listed below are publications that use Tocris products. Selected citations for Doxazosin mesylate include:

4 Citations: Showing 1 - 4

The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Authors: Kahn Et al.
EMBO Mol Med 2016;8:511
Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by DA in the Basolateral Amygdala.
Authors: Diaz Et al.
Front Cell Neurosci 2014;2:46
DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels.
Authors: Cilz Et al.
Cereb Cortex 2014;24:3195
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
Authors: Jahchan Et al.
Cancer Discov 2013;3:1364

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