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DPO-1

Catalog #: 2533
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2533/10
2533/50
DPO-1 | CAS No. 43077-30-1 | Voltage-gated Potassium Channel Blockers
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Description: Blocker of KV1.5 channel and IKur current
Alternative Names: Diphenyl phosphine oxide-1

Chemical Name: [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide

Purity: ≥99%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

Technical Data

M.Wt:
340.44
Formula:
C22H29OP
Solubility:
Soluble to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
43077-30-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DPO-1

The citations listed below are publications that use Tocris products. Selected citations for DPO-1 include:

5 Citations: Showing 1 - 5

  1. Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation.
    Authors: Ryland Et al.
    Mol Cancer Res  2016;14:26
  2. Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress.
    Authors: Ryland Et al.
    Oncogene  2015;34:4591
  3. Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit.
    Authors: Tabarean
    Pharmacol Res Perspect  2014;9:e96643
  4. Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells.
    Authors: Zhao Et al.
    PLoS One  2013;8:e64629
  5. Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents.
    Authors: Haim Et al.
    J Mol Cell Cardiol  2010;48:395

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