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DS2

Catalog #: 3679
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3679/10
3679/50
DS2 | CAS No. 374084-31-8 | GABA-A Receptor Modulators
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Description: Positive allosteric modulator of GABAA receptors; displays subunit selectivity

Chemical Name: 4-Chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide

Purity: ≥97%

Product Details
Citations (8)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DS2 is a positive allosteric modulator of GABAA receptors. Potentiates GABA-evoked currents mediated by α4β3δ receptors (EC50 = 142 nM, in vitro). Displays complex selectivity profile, with selectivity for δ-containing receptors (α4/6βxδ > α1βxδ >> γ2 > α4β3 GABAA receptors). Enhances tonic currents of thalamocortical neurons in wild-type mice.

Technical Data

M.Wt:
353.83
Formula:
C18H12ClN3OS
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥97%
Storage:
Desiccate at +4°C
CAS No:
374084-31-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DS2

The citations listed below are publications that use Tocris products. Selected citations for DS2 include:

8 Citations: Showing 1 - 8

  1. Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors.
    Authors: Olander Et al.
    Biochem Pharmacol  2018;150:305
  2. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Neurosci  2016;36:607
  3. Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
    Authors: Tong Et al.
    J Neurosci  2015;35:16142
  4. Functional characterization of the 1,5-benzodiazepine clo. and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.
    Authors: Hammer Et al.
    PLoS One  2015;10:e0120239
  5. Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site.
    Authors: Mirheydari Et al.
    Neurochem Res  2014;39:1057
  6. Synaptic GABAA receptor clustering without the γ2 subunit.
    Authors: Kerti-Szigeti Et al.
    Nat Methods  2014;34:10219
  7. Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function.
    Authors: Mennerick Et al.
    Psychopharmacology (Berl)  2014;231:3493
  8. Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.
    Authors: Shu Et al.
    Br J Pharmacol  2012;165:2228

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