Dynole 34-2
Chemical Name: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Purity: ≥99%
Biological Activity
Dynole 34-2 is a dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles.
Hill et al.
J.Med.Chem., 2009;52:3762 -
Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis.
Hill et al.
J.Med.Chem., 2010;53:4094
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Citations for Dynole 34-2
The citations listed below are publications that use Tocris products. Selected citations for Dynole 34-2 include:
4 Citations: Showing 1 - 4
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Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults.
Authors: Alisha Et al.
Elife 2022;11
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Dynamin regulates the fusion pore of endo- and exocytotic vesicles as revealed by membrane capacitance measurements.
Authors: Lasic
Biochim Biophys Acta 2017;1861(9):2293
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Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors.
Authors: Han Et al.
Am J Physiol Cell Physiol 2015;290:325
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Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP).
Authors: Henri J Et al.
PLoS One 2014;9:e98619
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