Home / Voltage-gated Potassium Channel Blockers / E-4031 dihydrochloride

E-4031 dihydrochloride

Catalog #: 1808
11 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1808/10
1808/50
E-4031 dihydrochloride | CAS No. 113559-13-0 | Voltage-gated Potassium Channel Blockers
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Description: KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

Chemical Name: N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

Purity: ≥98%

Product Details
Citations (11)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

E-4031 dihydrochloride is a selective blocker of KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents. Class III antiarrhythmic agent.

Technical Data

M.Wt:
474.44
Formula:
C21H27N3O3S.2HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
113559-13-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for E-4031 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for E-4031 dihydrochloride include:

11 Citations: Showing 1 - 10

  1. Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.
    Authors: Song Et al.
    Nat.Card.Res.  2022;1:142
  2. Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel.
    Authors: Veldkamp Et al.
    Nat Commun  2018;9:4357
  3. Electrophysiological measurement of ion channels on plasma/organelle membranes using an on-chip lipid bilayer system.
    Authors: Kamiya Et al.
    Sci Rep  2018;8:17498
  4. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
    Authors: McKeithan Et al.
    Front Physiol  2017;8:766
  5. Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells.
    Authors: Zhang Et al.
    Stem Cell Res  2017;20:21
  6. Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
    Authors: Pei Et al.
    Stem Cell Res  2017;19:94
  7. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria.
    Authors: Bragança Et al.
    Front Pharmacol  2016;7:45
  8. Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel.
    Authors: Zhang Et al.
    PLoS One  2015;8:10239
  9. Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways.
    Authors: Guo Et al.
    Curr Protoc Chem Biol  2015;7:141
  10. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.
    Authors: Yu Et al.
    Int J Clin Exp Pathol  2014;9:e96691

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