Echistatin, α1 isoform
Purity: ≥95%
Biological Activity
Echistatin, α1 isoform is a potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) receptors (IC50 = 30 nM) in vitro.Technical Data
(Modifications: Disulfide bridges: 2-11, 7-32, 8-37, 20-39)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins RGD-containing peptides from viper venoms.
Musial et al.
Circulation, 1990;82:261 -
Echistatin is a potent inhibitor of bone resorption in culture.
Sato et al.
J.Cell.Biol., 1990;111:1713 -
Biochemical characteriation of the binding of echistatin to integrin αVβ3 receptor.
Kumar et al.
J.Pharmacol.Exp.Ther., 1997;283:843
Product Datasheets
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Citations for Echistatin, α1 isoform
The citations listed below are publications that use Tocris products. Selected citations for Echistatin, α1 isoform include:
2 Citations: Showing 1 - 2
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Angiopoietin-like 3 induces podocyte F-actin rearrangement through integrin α(V)β3/FAK/PI3K pathway-mediated Rac1 activation.
Authors: Lin Et al.
PLoS One 2013;2013:135608
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Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells.
Authors: Schrader Et al.
Biomed Res Int 2011;53:1192
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