Home / 5-HT6 Receptor Agonists / EMD 386088 hydrochloride

EMD 386088 hydrochloride

Catalog #: 2382
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2382/10
2382/50
EMD 386088 hydrochloride | CAS No. 1171123-46-8 | 5-HT6 Receptor Agonists
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Description: Potent 5-HT6 agonist

Chemical Name: 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity

EMD 386088 hydrochloride is a potent 5-HT6 receptor agonist (EC50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM).

Technical Data

M.Wt:
283.2
Formula:
C14H15N2Cl.HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1171123-46-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.
    Mattsson et al.
    Bioorg.Med.Chem.Lett., 2005;15:4230

Product Datasheets

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Citations for EMD 386088 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for EMD 386088 hydrochloride include:

3 Citations: Showing 1 - 3

  1. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
    Authors: Hirono
    Neuropharmacology  2017;118:79
  2. Activation of 5-HT6 receptors modulates sleep-wake activity and hippocampal theta oscillation.
    Authors: Ly Et al.
    ACS Chem Neurosci  2013;4:191
  3. Excess of serotonin affects neocortical pyramidal neuron migration.
    Authors: Riccio Et al.
    Transl Psychiatry  2011;1:e47

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