Endothelin 1 (human, porcine)

Catalog #: 1160
16 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1160/100U

1 Image

Description: Potent vasoconstrictor peptide

Alternative Names: ET-1

Purity: ≥95%

View All Products for Non-selective Endothelin Receptor Agonists

Product Details

Citations (16)

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Biological Activity

Endothelin 1 (human, porcine) is an endogenous potent vasoconstrictor peptide that is an agonist at ET_A and ET_B receptors. Modulates vascular tone.

Technical Data

M.Wt:

2492

Formula:

C₁₀₉H₁₅₉O₃₂N₂₅S₅

Sequence:

CSCSSLMDKECVYFCHLDIIW

(Modifications: Disulfide bridges 1-15, 3-11)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

117399-94-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
Inoue et al.
Proc.Natl.Acad.Sci.U.S.A., 1989;86:2863
Involvement of ET_A and ET_B receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes.
Servitja et al.
Br.J.Pharmacol., 1998;124:1728
Primary structure, synthesis, and biological activity of rat endothelin, and endothelium-derived vasoconstrictor peptide.
Yanagisawa et al.
Proc.Natl.Acad.Sci.U.S.A., 1988;85:6964
Molecular biology and biochemistry of the endothelins.
Yanagisawa and Masaski
TiPS, 1989;10:374

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Citations for Endothelin 1 (human, porcine)

The citations listed below are publications that use Tocris products. Selected citations for Endothelin 1 (human, porcine) include:

16 Citations: Showing 1 - 10

The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes.
Authors: Cheng Et al.
Theranostics 2019;9:4287
S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension.
Authors: Ban Et al.
Redox Biol 2019;21:101099
Fasudil preserves lung endothelial function and reduces pulmonary vascular remodeling in a rat model of end-stage pulmonary hypertension with left heart disease.
Authors: Zhuang Et al.
Int J Mol Med 2018;42:1341
Dynamics and Functional Role of Dopaminergic Neurons in the Ventral Tegmental Area during Itch Processing.
Authors: Yuan Et al.
J Neurosci 2018;38:9856
Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy.
Authors: Zheng Et al.
Front Pharmacol 2017;8:222
IL-11 is a crucial determinant of cardiovascular fibrosis.
Authors: Schafer Et al.
Nature 2017;552:110
Endothelial cells enhance the migration of bovine meniscus cells.
Authors: Yuan Et al.
J Neurosci 2015;67:182
The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow.
Authors: Needham Et al.
J Pharmacol Exp Ther 2014;55:2157
Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors.
Authors: Sánchez Et al.
Br J Pharmacol 2014;171:5682
UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes.
Authors: Bellono Et al.
J Gen Physiol 2014;143:203

Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
Authors: Hamby Et al.
Invest Ophthalmol Vis Sci 2012;32:14489

Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.
Authors: Suri Et al.
Br J Pharmacol 2010;159:566

Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway.
Authors: Giachini Et al.
Am J Physiol Heart Circ Physiol 2009;296:H489

Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
Authors: McQueen Et al.
Br J Pharmacol 2007;151:278

Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
Authors: Khan Et al.
Br J Pharmacol 2006;147:607

Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
Authors: Cirino Et al.
Arthritis Rheumatol 2003;100:5531

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