Erastin
Chemical Name: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Purity: ≥98%
Biological Activity
Erastin is an antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.
Dolma et al.
Cancer Cell, 2003;3:285 -
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.
Yagoda et al.
Nature, 2007;447:864 -
Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Dixon et al.
Cell, 2012;149:1060
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Citations for Erastin
The citations listed below are publications that use Tocris products. Selected citations for Erastin include:
4 Citations: Showing 1 - 4
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Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair.
Authors: Koki Et al.
Cell Rep 2022;41:111610
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Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers.
Authors: Frank Et al.
Cancer Res 2020;80:1630-1643
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Metadherin enhances vulnerability of cancer cells to ferroptosis.
Authors: Bi Et al.
Cell Death Dis 2019;10:682
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Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine.
Authors: Wei Et al.
Nat Commun 2019;10:3646
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