Etoposide
Chemical Name: [5R-[5α,5aβ,8aα,9β(R*)]]-9-[(4,6-Ο-Ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-(5aH)-one
Purity: ≥99%
Biological Activity
Etoposide is a DNA topoisomerase II inhibitor (IC50 = 59.2 μM). Anticancer. Also enhances adeno-associated virus (AAV) transduction of HeLa cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Toposiomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes.
Burden et al.
J.Biol.Chem., 1996;271:29238 -
Etoposide: four decades of development of a topoisomerase II inhibitor.
Hande et al.
Eur.J.Cancer, 1998;34:1514 -
Antitumor agents.3.Synthesis and biological activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.
Terada et al.
J.Med.Chem., 1993;36:1689 -
Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens.
Nicolson et al.
J.Virol., 2016;90:7019
Product Datasheets
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Citations for Etoposide
The citations listed below are publications that use Tocris products. Selected citations for Etoposide include:
4 Citations: Showing 1 - 4
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Novel peptide dermaseptin-PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling.
Authors: Long Et al.
J Cell Mol Med 2019;23:1300
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Etoposide incorporated into camel milk phospholipids liposomes shows increased activity against fibrosarcoma in a mouse model.
Authors: Maswadeh Et al.
Eur J Cancer 2015;2015:743051
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Recombinant adeno-associated virus utilizes host cell nuclear import machinery to enter the nucleus.
Authors: Nicolson
J Virol 2014;88:4132
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Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis.
Authors: Li Et al.
J Biol Chem 2013;288:17908
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