ETP 45835 dihydrochloride
Chemical Name: 4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]pyridine dihydrochloride
Purity: ≥99%
Biological Activity
ETP 45835 dihydrochloride is a Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.
Oyarzabal et al.
J.Med.Chem., 2010;53:6618
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Citation for ETP 45835 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ETP 45835 dihydrochloride include:
1 Citation: Showing 1 - 1
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Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma.
Authors: Ichiyanagi Et al.
Oncotarget 2019;10:4053
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