FAM-DEALAHypYIPMDDDFQLRSF

Catalog #: 7452 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
7452/1

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Description: Fluorescent HIF-1α peptide; can be used to evaluate the effect of VHL binding on degradation activity

Purity: ≥95%

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Biological Activity

FAM-DEALAHypYIPMDDDFQLRSF is a 5-carboxyfluorescein (FAM) labeled HIF-1α peptide. It binds with high affinity to von Hippel-Lindau (VHL) protein (K_D = 3 nM). Can be used to assess ligand binding to VHL in a direct fluorescence polarization (FP) displacement assay. Excitation/emission maxima (λ) = 485/520 nm. This product is a longer peptide version of FAM-DEALA-Hyp-YIPD (Cat. No. 7287).

Optical Data for FAM-DEALAHypYIPMDDDFQLRSF

Emission Color	Green
λ_abs	485 nm
λ_em	520 nm
Closest Laser line	488 nm
Application	Fluorescence Polarization (FP) Displacement Assays

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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Technical Data

M.Wt:

2616.76

Formula:

C₁₂₂H₁₅₈N₂₄O₃₉S

Sequence:

DEALAXYIPMDDDFQLRSF

(Modifications: Asp-1 = 5-FAM-Asp, X-6 = Hyp, Phe-19 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in PBS (pH 7.4)

Purity:

≥95%

Storage:

Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Identification and characterization of Von Hippel-Lindau-recruiting proteolysis targeting chimeras (PROTACs) of TANK-binding kinase 1.
Crew et al.
J.Med.Chem., 2018;61:583

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