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Fenoldopam hydrochloride

Catalog #: 1659
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Fenoldopam hydrochloride | CAS No. 181217-39-0 | Dopamine D1 and D5 Receptor Agonists
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Description: Selective D1-like partial agonist
Alternative Names: SKF 82526

Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Fenoldopam hydrochloride is a selective D1-like dopamine receptor partial agonist (EC50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α2-adrenoceptor antagonist in vitro (Ki = 15 - 25 nM).

Technical Data

M.Wt:
342.22
Formula:
C16H16ClNO3.HCl
Solubility:
Soluble to 10 mM in water
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
181217-39-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Characterization of the peripheral and central effects of SK&F 82526, a novel DA receptor agonist.
    Hahn et al.
    J.Pharmacol.Exp.Ther., 1982;223:305
  2. Interactions of novel DArgic ligands with D-1 and D-2 DA receptors.
    Sibley et al.
    Life Sci., 1982;31:637
  3. The pharmacology of fenol.
    Nichols et al.
    Am.J.Hypertens., 1990;3:116S

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Citation for Fenoldopam hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Fenoldopam hydrochloride include:

1 Citation: Showing 1 - 1

  1. Gastrin and D1 DA receptor interact to induce natriuresis and diuresis.
    Authors: Chen Et al.
    Hypertension  2013;62:927

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