Filipin III
Chemical Name: (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-Octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Purity: ≥90%
Biological Activity
Filipin III is a polyene antibiotic. Binds sterols in fungal membranes. Also inhibits formation of the pathological form of prion protein (PrP-res) from the normal membrane-bound (PrP-sen) form. Also fluorescent cholesterol stain.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.
Pipalia et al.
J.Lipid Res., 2006;47:284 -
Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol.
Castanho et al.
J.Biol.Chem., 1992;267:204 -
Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.
Marella et al.
J.Biol.Chem., 2002;277:25457
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