Home / Class I Histone Deacetylases Inhibitors / FK 228

FK 228

Catalog #: 3515
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3515/1
FK 228 | CAS No. 128517-07-7 | Class I Histone Deacetylases Inhibitors
1 Image
Description: Potent and selective class I histone deacetylase inhibitor; antitumor
Alternative Names: Depsipeptide, FR 901228, Romidepsin

Chemical Name: Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5) disulfide

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

FK 228 is a potent and selective inhibitor of class I histone deacetylases (HDACs) (IC50 values are 36, 47, 510 and 14,000 nM for HDAC1, HDAC2, HDAC4 and HDAC6 respectively). Exhibits cytotoxicity against various human tumor cell lines; also exhibits antitumor activity against human tumor xenografts.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Romidepsin is reviewed on the Chemical Probes website.

Technical Data

M.Wt:
540.7
Formula:
C24H36N4O6S2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
128517-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for FK 228

The citations listed below are publications that use Tocris products. Selected citations for FK 228 include:

4 Citations: Showing 1 - 4

  1. NF-κB-dependent repression of Sox18 transcription factor requires the epigenetic regulators histone deacetylases 1 and 2 in acute lung injury.
    Authors: Ting Et al.
    Front Physiol  2022;13:947537
  2. INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury.
    Authors: Steven L Et al.
    Nat Commun  2022;13:6037
  3. Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer.
    Authors: Pozo Et al.
    Oncotarget  2018;9:37662
  4. Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage.
    Authors: Fukuda Et al.
    J Pharmacol Exp Ther  2015;106:1050

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for FK 228

There are currently no reviews for this product. Be the first to review FK 228 and earn rewards!

Have you used FK 228?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.