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Flavopiridol hydrochloride

Catalog #: 3094
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Flavopiridol hydrochloride | CAS No. 131740-09-5 | Cyclin-dependent Kinase Inhibitors
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Description: Cdk inhibitor; potently inhibits cdk2 and cdk9
Alternative Names: L 86-8275

Chemical Name: 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Flavopiridol hydrochloride is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and <0.85 μM for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.

Technical Data

M.Wt:
438.3
Formula:
C21H20ClNO5.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
131740-09-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275.
    Kaur et al.
    J.Natl.Cancer.Inst., 1992;84:1736
  2. The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
    Ambrosini et al.
    Cancer Res., 2008;68:2312
  3. How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
    Jorda et al.
    J.Med.Chem., 2018;61:9105
  4. Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275.
    Losiewicz et al.
    Biochem.Biophys.Res.Comm., 1994;201:589

Product Datasheets

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Citation for Flavopiridol hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Flavopiridol hydrochloride include:

1 Citation: Showing 1 - 1

  1. Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage.
    Authors: Stork Et al.
    Elife  2016;5

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