Fluvoxamine maleate
Chemical Name: (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate
Purity: ≥99%
Biological Activity
Fluvoxamine maleate is a selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a Ki of 1.6 nmol/l.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
Owens et al.
J.Pharmacol.Exp.Ther., 1997;283:1305 -
Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor.
Classen et al.
Br.J.Pharmacol., 1977;60:505 -
Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
Benfield and Ward
Drugs, 1986;32:313 -
Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain.
Narita et al.
Eur.J.Pharmacol., 1996;307:117
Product Datasheets
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Citations for Fluvoxamine maleate
The citations listed below are publications that use Tocris products. Selected citations for Fluvoxamine maleate include:
8 Citations: Showing 1 - 8
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Effects of BD1047, a σ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells.
Authors: Su Et al.
PLoS One 2014;7:435
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Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter.
Authors: Nolan Et al.
ACS Chem Neurosci 2014;5:784
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TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity.
Authors: Agarwal Et al.
World J Gastroenterol 2013;8:e63028
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A 96-well filtration method for radioligand binding analysis of σ receptor ligands.
Authors: Fishback Et al.
J Pharm Biomed Anal 2012;71:157
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Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production.
Authors: Wood Et al.
J Neurosci 2011;31:13808
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The anti-inflammatory drug leflun. is an agonist of the aryl hydrocarbon receptor.
Authors: O'Donnell Et al.
PLoS One 2010;5
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Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors.
Authors: Hirano Et al.
Br J Pharmacol 2005;144:695
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Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs.
Authors: Kobayashi Et al.
Neuropsychopharmacology 2004;29:1841
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