FMF-04-159-2

Catalog # Availability Size / Price Qty
7158/10
FMF-04-159-2 | CAS No. 2364489-81-4 | Cyclin-dependent Kinase Inhibitors
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Description: Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

Chemical Name: N-[1-[[3-[[(2E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]phenyl]sulfonyl]-4-piperidinyl]-4-[(2,4,6- trichlorobenzoyl)amino]-1H-pyrazole-3-carboxamide

Purity: ≥98%

Product Details
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Biological Activity

FMF-04-159-2 is a potent inhibitor of CDK14 and CDK16 (IC50 = 40 nM for CDK14 in cellular BRET assay; IC50 values are 88 and 10 nM for CDK14 and CDK16 in kinase activity inhibition assay, respectively). Inhibits other TAIRE kinase family members at 1 μM (CDK17 and CDK18). Also binds CDK2 (IC50 = 256 nM). Displays covalent binding of CDK14, with binding sustained after washout. Causes cell cycle arrest at G2/M in cancer cell lines.

Reversible control FMF-04-159-R (Cat. No. 7159) also available.

Technical Data

M.Wt:
683.01
Formula:
C28H30Cl3N7O5S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2364489-81-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

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