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FX 1

Catalog #: 6323 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6323/5
6323/25
FX 1 | CAS No. 1426138-42-2 | Bcl-2 Family Inhibitors
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Description: Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors

Chemical Name: (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid

Purity: ≥98%

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Biological Activity

FX 1 is a Bcl-6 inhibitor (Kd = 3 μM); exhibits 10-fold greater potency than endogenous Bcl-6 corepressors. Disrupts formation of Bcl-6 repression complex. Induces regression of established tumors in mice bearing DLBCL xenograft.

Technical Data

M.Wt:
368.82
Formula:
C14H9ClN2O4S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1426138-42-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.
    Cardenas et al.
    J.Clin.Invest., 2016;126:3351
  2. The expanding role of the BCL6 oncoprotein as a cancer therapeutic target.
    Cardenas et al.
    Clin.Cancer Res., 2017;23:885

Product Datasheets

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