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G 5555

Catalog #: 6051
1 Citation Datasheet / COA / SDS
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6051/10
6051/50
G 5555 | CAS No. 1648863-90-4 | PAK Inhibitors
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Description: High affinity group I PAK inhibitor

Chemical Name: 8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

G 5555 is a high affinity group 1 PAK (pan-PAK1, 2 and 3) inhibitor (Ki = 3.7 nM; pMEK IC50 = 69 nM). Of 235 kinases tested, other than PAK1, eight (PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1) were inhibited >70%. Exhibits low hERG channel activity (<50% inhibition at 10 μM). Orally bioavailable.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of G 5555 is reviewed on the chemical probes website.

Technical Data

M.Wt:
492.96
Formula:
C25H25ClN6O3
Solubility:
Soluble to 100 mM in 1eq. HCl and to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1648863-90-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for G 5555

The citations listed below are publications that use Tocris products. Selected citations for G 5555 include:

1 Citation: Showing 1 - 1

  1. PAK1 Positively Regulates Oligodendrocyte Morphology and Myelination.
    Authors: Teresa L Et al.
    J Neurosci  2021;41:1864-1877

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