Gadolinium chloride
Biological Activity
Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Focal adhesion kinase signaling regulates anti-inflammatory function of bone marrow mesenchymal stromal cells induced by biomechanical force
HJ Lee, MF Diaz, A Ewere, SD Olson, CS Cox, PL Wenzel
Cell. Signal., 2017;38(0):9-Jan. -
Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels.
Nishitani et al.
PLoS One., 2011;6:e26181 -
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Lee et al.
Nature, 2012;492:123 -
The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells.
Del Favero et al.
Chem.Res.Toxicol., 2012;25:1912 -
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration.
Nagata et al.
Proc.Natl.Acad.Sci.U.S.A., 2008;105:353
Product Datasheets
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Citations for Gadolinium chloride
The citations listed below are publications that use Tocris products. Selected citations for Gadolinium chloride include:
6 Citations: Showing 1 - 6
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Role of Ion Channels in the Maintenance of Sperm Motility and Swimming Behavior in a Marine Teleost.
Authors: François Et al.
Int J Mol Sci 2022;23
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Augmented KCa2.3 Channel Feedback Regulation of Oxytocin Stimulated Uterine Strips from Nonpregnant Mice.
Authors: Mark S Et al.
Int J Mol Sci 2021;22
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Binding Dynamics of α-Actinin-4 in Dependence of Actin Cortex Tension.
Authors: Ina Et al.
Biophys J 2020;119:1091-1107
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Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation.
Authors: Dela Paz
Biochem Biophys Res Commun 2018;497(1):220
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Quantum dots modulate intracellular Ca2+level in lung epithelial cells.
Authors: Yin Et al.
Int J Nanomedicine 2017;12:2781
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Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons.
Authors: Szteyn Et al.
J Immunol 2015;7
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