Home / Nuclear Receptor Agonists / GC 1

GC 1

Catalog #: 4554
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4554/10
4554/50
GC 1 | CAS No. 211110-63-3 | Nuclear Receptor Agonists
1 Image
Description: High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic
Alternative Names: Sobetirome

Chemical Name: 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.

Technical Data

M.Wt:
328.4
Formula:
C20H24O4
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
211110-63-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for GC 1

The citations listed below are publications that use Tocris products. Selected citations for GC 1 include:

5 Citations: Showing 1 - 5

  1. Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway.
    Authors: Ning Et al.
    Cell Death Dis  2023;14:51
  2. Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis.
    Authors: Wei Et al.
    J Hepatol  2019;70:1170-1179
  3. Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing.
    Authors: Gonzalez-Hurtado Et al.
    Mol Metab  2018;7:45
  4. Ins. mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.
    Authors: Balboa Et al.
    Elife  2018;7
  5. Clobetasol promotes remyelination in a mouse model of neuromyelitis optica.
    Authors: Yao Et al.
    Acta Neuropathol Commun  2016;4:42

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for GC 1

There are currently no reviews for this product. Be the first to review GC 1 and earn rewards!

Have you used GC 1?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.