Home / Protein Kinase C Inhibitors / Go 6983

Go 6983

Catalog #: 2285
25 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2285/1
2285/10
Go 6983 | CAS No. 133053-19-7 | Protein Kinase C Inhibitors
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Description: Broad spectrum PKC inhibitor
Alternative Names: Goe 6983

Chemical Name: 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Purity: ≥98%

Product Details
Citations (25)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Go 6983 is a broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).

Technical Data

M.Wt:
442.51
Formula:
C26H26N4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
133053-19-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Derivation of novel human ground state naive pluripotent stem cells.
    Gafni O, Weinberger L, Mansour AA et al.
    Nature
  2. Specific activation of the G protein-coupled receptor BNGR-A21 by the neuropeptide corazonin from the silkworm, Bombyx mori, dually couples to the G(q) and G(s) signaling cascades.
    Yang, Jingwen, Huang, Haishan, Yang, Huipeng, He, Xiaobai, Jiang, Xue, Shi, Ying, Alatangaole, Damirin, Shi, Liangen, Zhou, Naiming
    J Biol Chem, 2013;288(17):11662-75.
  3. Protein kinase D1 (PKD1) phosphorylation on Ser(203) by type I p21-activated kinase (PAK) regulates PKD1 localization
    JK Chang, Y Ni, L Han, J Sinnett-Sm, R Jacamo, O Rey, SH Young, E Rozengurt
    J. Biol. Chem., 2017;0(0):.
  4. Protein kinase C-alpha downregulates estrogen receptor-alpha by suppressing c-Jun phosphorylation in estrogen receptor-positive breast cancer cells.
    Kim S, Lee J, Lee S, Bae S, Kim J, Kim M, Kil W, Kim S, Lee J, Nam S
    Oncol Rep, 2014;31(3):1423-8.
  5. The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway.
    Uhlenbrock F, Hagemann-Jensen M, Kehlet S, Andresen L, Pastorekova S, Skov S
    J Immunol, 2014;193(4):1654-65.
  6. BNGR-A25L and -A27 are two functional G protein-coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm, Bombyx mori
    Z Shen, Y Chen, L Hong, Z Cui, H Yang, X He, Y Shi, L Shi, F Han, N Zhou
    J. Biol. Chem., 2017;0(0):.
  7. Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes.
    Gschwendt et al.
    FEBS Lett., 1996;392:77
  8. Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion.
    Peterman et al.
    J.Cardiovasc.Pharmacol., 2004;43:645
  9. Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.
    Young et al.
    Cardiovasc.Drug Rev., 2005;23:255
  10. Human naive epiblast cells possess unrestricted lineage potential
    G Guo, GG Stirparo, SE Strawbridg, D Spindlow, J Yang, J Clarke, A Dattani, A Yanagida, MA Li, S Myers, BN Özel, J Nichols, A Smith
    Cell Stem Cell, 2021;0(0):.

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Citations for Go 6983

The citations listed below are publications that use Tocris products. Selected citations for Go 6983 include:

25 Citations: Showing 1 - 10

  1. Multiple sources of signal amplification within the B-cell Ras/MAPK pathway.
    Authors: Mclaurin and Weiner
    Mol Biol Cell  2019;30:1610
  2. Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution.
    Authors: Messmer Et al.
    Cell Rep  2019;26:815
  3. Capacitation of human na�ve pluripotent stem cells for multi-lineage differentiation.
    Authors: Rostovskaya Et al.
    Development  2019;146
  4. A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells.
    Authors: Fang Et al.
    Nat Commun  2018;9:4384
  5. Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish.
    Authors: Liu Et al.
    Transl Psychiatry  2018;8:232
  6. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
    Authors: Schaffer Et al.
    Cell Rep  2018;25:2470
  7. CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons.
    Authors: Carriba
    Elife  2017;6
  8. Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
    Authors: Zhang Et al.
    J Exp Med  2017;214:2671
  9. Reduced ins. signaling maintains electrical transmission in a neural circuit in aging flies.
    Authors: Augustin Et al.
    PLoS Biol  2017;15:e2001655
  10. AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons.
    Authors: Tuvikene Et al.
    J Neurosci  2016;36:1290
  11. Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.
    Authors: Li Et al.
    J Clin Invest  2016;126:389
  12. CD24 tracks divergent pluripotent states in mouse and human cells.
    Authors: Shakiba Et al.
    J Biol Chem  2015;6:7329
  13. Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons.
    Authors: Devinney Et al.
    Proc Natl Acad Sci U S A  2015;35:8107
  14. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
    Authors: Toda and Huganir
    Nat Commun  2015;112:6712
  15. Ets and GATA Transcription Factors Play a Critical Role in PMA-Mediated Repression of the ckβ Promoter via the Protein Kinase C Signaling Pathway.
    Authors: Kuan Et al.
    Biol Chem  2014;9:e113485
  16. NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation.
    Authors: Cavaliere Et al.
    Cell Signal  2014;7:261
  17. Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins.
    Authors: Yi Et al.
    Neuron  2014;289:30101
  18. Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes.
    Authors: Pakpour Et al.
    PLoS One  2013;8:e76535
  19. GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas.
    Authors: Atwood Et al.
    J Neurosci  2013;494:484
  20. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
    Authors: Vliet Et al.
    J Biol Chem  2013;288:27519
  21. Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency.
    Authors: Rajendran Et al.
    J Biol Chem  2013;288:24351
  22. γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway.
    Authors: Garrett Et al.
    PLoS One  2012;74:269
  23. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.
    Authors: Scarisbrick Et al.
    Front Cell Neurosci  2012;393:355
  24. Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1.
    Authors: Baskin and Sayeski
    BMC Complement Altern Med  2012;24:435
  25. Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance.
    Authors: Dutta Et al.
    Stem Cells  2011;29:618

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