GR 125487 sulfamate
Chemical Name: 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate
Purity: ≥97%
Biological Activity
GR 125487 sulfamate is a potent and selective 5-HT4 receptor antagonist (Ki = 0.19 nM for porcine 5-HT4). Centrally active following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Role of 5-HT4 receptors in the mouse passive avoidance test.
Galeotti et al.
J.Pharmacol.Exp.Ther., 1998;286:1115 -
Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding.
Schiavi et al.
Neuropharmacology, 1994;33:543 -
Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the emesis induced by high-dose cisp. in Suncus murinus.
Horikoshi et al.
Jpn.J.Pharmacol., 2001;85:70
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Citations for GR 125487 sulfamate
The citations listed below are publications that use Tocris products. Selected citations for GR 125487 sulfamate include:
2 Citations: Showing 1 - 2
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Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
Authors: Orr Et al.
J Neurosci 2015;18:423
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Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation.
Authors: Warner-Schmidt Et al.
Dis Model Mech 2009;29:1937
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