Halofuginone hydrobromide

Catalog # Availability Size / Price Qty
1993/50
Halofuginone hydrobromide | CAS No. 64924-67-0 | Synthase/Synthetase Inhibitors
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Description: High affinity competitive prolyl-tRNA synthetase inhibitor

Chemical Name: (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide

Purity: ≥98%

Product Details
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Biological Activity

Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.

Technical Data

M.Wt:
495.59
Formula:
C16H17BrClN3O3.HBr
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
64924-67-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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