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Hh-Ag1.5

Catalog #: 7807 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7807/1
7807/5
Hh-Ag1.5 | CAS No. 612542-14-0 | Smoothened
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Description: Potent and high affinity Smo receptor agonist

Chemical Name: 3-Chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide

Purity: ≥98%

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Biological Activity

Hh-Ag1.5 is a potent and high affinity Smoothened (Smo) receptor agonist (EC50 = 1 nM; Ki values are 0.5 and 2.3 nM respectively, in a [3H]SAG-1.3 and [3H]Cyclopamine binding assay). It is used in protocols for the chemical reprogramming of mouse embryonic fibroblasts into neural stem cells. Also induces differentiation of hiPSCs into skin-derived precursor cells, spinal motor neurons and spinal sensory neurons.

Technical Data

M.Wt:
526.04
Formula:
C28H26ClF2N3OS
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
612542-14-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
    Rominger et al.
    J.Pharmacol.Exp.Ther., 2009;329:995

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