HS 024

Catalog #: 1832
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1832/1

1 Image

Description: Highly potent MC4 receptor antagonist

Purity: ≥95%

View All Products for Melanocortin Receptor Antagonists

Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

HS 024 is a highly potent melanocortin MC₄ receptor antagonist (K_i values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC₄, MC₁, MC₃ and MC₅ receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.

Technical Data

M.Wt:

1266.5

Formula:

C₅₈H₇₉N₁₉O₁₀S₂

Sequence:

CXRHXRWGC

(Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge: 1-9)

Solubility:

Soluble to 0.50 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

212370-59-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Melanocortin receptor agonist transiently increases oxygen consumption in rats.
Jonsson et al.
Neuroreport, 2001;12:3703
Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats.
Jonsson et al.
J.Endocrinol., 2002;173:517
Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo.
Kask et al.
Endocrinology, 1998;139:5006

Product Datasheets

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Citations for HS 024

The citations listed below are publications that use Tocris products. Selected citations for HS 024 include:

2 Citations: Showing 1 - 2

Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.
Authors: Nepomuceno Et al.
Front Pharmacol 2018;9:157
Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.
Authors: Simamura Et al.
J Neurochem 2015;10:e0123232

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