Human Activin RIA/ALK-2 Biotinylated Antibody Summary
Asp23-Glu123
Accession # Q04771
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Activin RIA/ALK-2
Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine‑threonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActR-I(A), ActR-IB, ActR-II(A), and ActR-IIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different high-affinities to the various type II isoforms. Type I activin receptors do not bind directly to activin but will associate with the type II receptor-activin complex and initiate signal transduction. Besides the activin isoforms, ActR-II will also bind inhibin, BMP-2 and BMP-7 with lower affinities. ActR-I can also bind and form signaling complexes with the BMP-2/7-bound BMPR-II. Activin type I receptors are highly conserved. Human, mouse and bovine type IA activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type I receptor does not bind activin.
- Attisano, L. et al. (1996) Mol. and Cell. Biol. 16:1066.
- Woodruff, T.K. (1998) Biochem. Pharmacology 55:953.
Product Datasheets
Citations for Human Activin RIA/ALK-2 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma.
Authors: Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J
PLoS ONE, 2012-10-01;7(10):e46117.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells.
Authors: Sivertsen EA, Huse K, Hystad ME, Kersten C, Smeland EB, Myklebust JH
Eur. J. Immunol., 2007-10-01;37(10):2937-48.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3.
Authors: Kersten C, Dosen G, Myklebust JH, Sivertsen EA, Hystad ME, Smeland EB, Rian E
Exp. Hematol., 2006-01-01;34(1):72-81.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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