Human AGTR-2 APC-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB3659A
Detection of AGTR‑2 in NS0 Mouse Cell Line by Flow Cytometry.
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Product Details
Citations (2)
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Human AGTR-2 APC-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human AGTR‑2. Stains human AGTR-2-transfected cells but not irrelevant transfectants.
Source
Monoclonal Mouse IgG2B Clone # 364805
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
HEK293 human embryonic kidney cell line transfected with human AGTR-2
Met1-Ser363
Accession # P50052
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of AGTR‑2 antibody in NS0 Mouse Cell Line antibody by Flow Cytometry. View Larger

Detection of AGTR‑2 in NS0 Mouse Cell Line by Flow Cytometry. NS0 mouse myeloma cell line was stained with Mouse Anti-Human AGTR-2 APC-conjugated Monoclonal Antibody (Catalog # FAB3659A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: AGTR-2

AGTR-2, also known as AT2, is a 7-transmembrane protein that belongs to family 1 of G protein-coupled receptors. Both AGTR-2 and AGTR‑1 bind Angiotensin II and function in the control of hemodynamics. In contrast to AGTR‑1, which promotes vasoconstriction and cell proliferation, AGTR-2 inhibits growth and promotes apoptosis. In addition, Angiotensin II-induced AGTR-2 signaling induces the release of nitric oxide in the heart, kidney, and brain and participates in tissue morphogenesis and repair. Human AGTR-2 shares 92% amino acid sequence identity with mouse and rat AGTR-2.

Long Name
Angiostensin II Type 2 Receptor
Entrez Gene IDs
186 (Human); 11609 (Mouse); 24182 (Rat)
Alternate Names
AGTR2; AGTR-2; Angiostensin Receptor; angiotensin II receptor, type 2; Angiotensin II type-2 receptor; angiotensin receptor 2; AT2; AT2ATGR2; AT2R; MRX88; MRX88type-2 angiotensin II receptor

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Citations for Human AGTR-2 APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Data supporting that adipose-derived mesenchymal stem/stromal cells express angiotensin II receptors in situ and in vitro
    Authors: LV Ageeva, VY Sysoeva, PA Tyurin-Kuz, GV Sharonov, DT Dyikanov, DV Stambolsky, NI Kalinina
    Data Brief, 2017-11-21;16(0):327-333.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Local angiotensin II promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptor
    Authors: VY Sysoeva, LV Ageeva, PA Tyurin-Kuz, GV Sharonov, DT Dyikanov, NI Kalinina, VA Tkachuk
    Stem Cell Res, 2017-11-03;25(0):115-122.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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