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Human alpha-Synuclein Biotinylated Antibody

Catalog #: BAF1338
6 Citations Datasheet / COA / SDS
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BAF1338
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Citations (6)
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Human alpha-Synuclein Biotinylated Antibody Summary

Species Reactivity
Human
Specificity
Detects human alpha -Synuclein in Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human alpha -Synuclein
Met1-Ala140
Accession # P37840
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Label
Biotin

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human alpha -Synuclein

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: alpha-Synuclein

alpha -Synuclein is a cytoplasmic protein that is predominantly expressed in the central nervous system. It is a minor protein found in amyloid deposition that is a hallmark of Alzheimer's disease. Defects in SNCA are associated with familial Parkinson's disease.

Entrez Gene IDs
6622 (Human); 20617 (Mouse); 29219 (Rat); 641350 (Porcine); 282857 (Bovine)
Alternate Names
alpha-Synuclein; I+/--synuclein; MGC110988; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; SNCA; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); Synuclein-alpha; truncated alpha synuclein

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Citations for Human alpha-Synuclein Biotinylated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas
    Authors: LI Sinclair, A Kumar, T Darreh-Sho, S Love
    Alzheimers Res Ther, 2019-09-12;11(1):80.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: ELISA Detection
  2. Transmission of ?-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease?
    Authors: J Matsumoto, T Stewart, L Sheng, N Li, K Bullock, N Song, M Shi, WA Banks, J Zhang
    Acta Neuropathol Commun, 2017-09-13;5(1):71.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Luminex Development
  3. Endothelin-converting enzymes degrade ?-synuclein and are reduced in dementia with Lewy bodies
    Authors: JS Miners, S Love
    J. Neurochem, 2017-03-29;0(0):.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: ELISA Development (Detection)
  4. Salivary total ?-synuclein, oligomeric ?-synuclein and SNCA variants in Parkinson's disease patients
    Authors: Wenyan Kang
    Sci Rep, 2016-06-23;6(0):28143.
    Species: Human
    Sample Types: Saliva
    Applications: Luminex Development
  5. Using gastrocnemius sEMG and plasma alpha-synuclein for the prediction of freezing of gait in Parkinson's disease patients.
    Authors: Wang X, Kang W, Yang Q, Zhang L, Chen S, Liu J
    PLoS ONE, 2014-02-27;9(2):e89353.
    Species: Human
    Sample Types: Plasma
    Applications: Bioassay
  6. DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease.
    Authors: Hong, Zhen, Shi, Min, Chung, Kathryn, Quinn, Joseph F, Peskind, Elaine R, Galasko, Douglas, Jankovic, Joseph, Zabetian, Cyrus P, Leverenz, James B, Baird, Geoffrey, Montine, Thomas J, Hancock, Aneeka M, Hwang, Hyejin, Pan, Catherin, Bradner, Joshua, Kang, Un J, Jensen, Poul H, Zhang, Jing
    Brain, 2010-02-15;133(0):713-26.
    Species: Human
    Sample Types: CSF
    Applications: Luminex Development

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