Human BMP-2/BMP-4 Antibody Summary
Gln283-Arg396
Accession # P12643
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
Alkaline Phosphatase Production Induced by BMP‑2 and Neutralization by Human BMP-2/BMP-4 Antibody. Recombinant Human BMP-2 (Catalog # 355-BM) induces alkaline phosphatase production in the the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline Phosphatase Production elicited by Recombinant Human BMP-2 (1 µg/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human BMP-2/BMP-4 Monoclonal Antibody (Catalog # MAB3552). The ND50 is typically 5-15 µg/mL in the presence of heparin (2 µg/mL).
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: BMP-2/BMP-4
Bone Morphogenetic Protein 2 (BMP-2) and BMP-4 are two of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor beta (TGF-beta ) superfamily, BMPs were originally identified as protein regulators of cartilage and bone formation. However, they have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs.
Product Datasheets
Citations for Human BMP-2/BMP-4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia
Authors: S Nagel, C Pommerenke, C Meyer, RAF MacLeod
International Journal of Molecular Sciences, 2022-03-16;23(6):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses
Authors: W Chen, SS Foo, E Hong, C Wu, WS Lee, SA Lee, D Evseenko, MEL Moreira, A García-Sas, G Cheng, K Nielsen-Sa, P Brasil, E Avvad-Port, JU Jung
Nature Microbiology, 2021-01-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis.
Authors: Martinez V, Sacedon R, Hidalgo L, Valencia J, Fernandez-Sevilla L, Hernandez-Lopez C, Vicente A, Varas A
PLoS ONE, 2015-06-25;10(6):e0131453.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Essential role of BMPs in FGF-induced secondary lens fiber differentiation.
Authors: Boswell BA, Overbeek PA, Musil LS
Dev. Biol., 2008-09-18;324(2):202-12.
Species: Chicken
Sample Types: Whole Cells
Applications: Neutralization -
Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.
Authors: Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW
J. Pathol., 2008-01-01;214(1):85-95.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.
Authors: Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T
Blood, 2007-05-31;110(6):2182-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia.
Authors: Rydziel S, Stadmeyer L, Zanotti S, Durant D, Smerdel-Ramoya A, Canalis E
J. Biol. Chem., 2007-05-10;282(27):19762-72.
Species: Mouse
Sample Types: Protein
Applications: Western Blot -
Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7.
Authors: Zhao M, Zhao Z, Koh JT, Jin T, Franceschi RT
J. Cell. Biochem., 2005-05-01;95(1):1-16.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Immunoprecipitation
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