Human Calsyntenin-1 Biotinylated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Calsyntenin-1

Calsyntenin-1 (CST-1; also Alcadein-alpha ) is a 140‑150 kDa member of the Alcadein family of molecules. It is expressed in the ER/Golgi and on the plasma membranes of almost all neurons. It is a calcium-binding protein that may regulate post-synaptic signaling and APP cleavage and gene activation. Notably, when cleaved in a manner similar to APP, its intracellular fragment antagonizes APP AICD gene activation. Mature human CST-1 is a 953 amino acid (aa) type I transmembrane protein. It contains two cadherin domains (aa 38‑265) in its extracellular region (aa 29‑859) and a 101 aa cytoplasmic tail. Extracellular cleavage occurs at Met825 Ala826, generating a soluble 115 kDa ECD. Isoforms involve a 78 aa substitution for aa 917‑981, plus deletions of aa 72‑81 and 507‑525. Over aa 30‑851, human CST-1 shares 92% aa identity with mouse CST-1.

Product Datasheets

Related Research Areas

• APP Processing and Amyloid Plaque Formation
• Calcium-binding Proteins and Related Molecules
• Synaptic Adhesion Molecules
• Synaptic Proteins