Human CCR5 Antibody

Name: Human CCR5 Antibody
Brand: R&D Systems
SKU: MAB1801
Rating: 1 (1 reviews)

Catalog #: MAB1801
6 Citations 1 Review Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB1801-100
MAB1801-SP

All CCR5 Antibodies

Product Details

Citations (6)

FAQs

Supplemental Products

Reviews (1)

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CCR5 Antibody Summary

Species Reactivity

Human

Specificity

Detects human CCR5 in direct ELISAs and Western blots. For additional information regarding epitope specificity for this antibody and other R&D Systems anti-human CCR5 antibodies, see reference 1 below.

Source

Monoclonal Mouse IgG₁ Clone # CTC8

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

CHO Chinese hamster ovary cell line transfected with human CCR5

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

Lee, B. et al. (1999) J. Biol. Chem. 274:9617.

Immunoprecipitation

Mirzabekov, T. et al. (1999) J. Biol. Chem. 274:28745.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CCR5

CCR5 is a G protein-linked seven transmembrane domain chemokine receptor. CCR5 serves as a receptor for several chemokines including MIP-1 alpha, MIP-1 beta, MCP-2, and RANTES. It also functions as a co‑receptor for Macrophage Tropic HIV-1 infection.

References

Lee, B. et al. (1999) J. Biol. Chem. 274:9617.

Entrez Gene IDs

1234 (Human); 12774 (Mouse); 117029 (Rat); 484789 (Canine); 493769 (Feline)

Alternate Names

C-C CKR-5; C-C motif chemokine receptor 5 A159A; CCCKR5; CC-CKR-5FLJ78003; CCR5; CCR-5; CD195 antigen; CD195; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; chemr13; CKR5; CKR-5; HIV-1 fusion coreceptor; IDDM22CMKBR5C-C chemokine receptor type 5

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human CCR5 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies
Authors: M Weichseldo, Y Tagaya, M Reitz, AL DeVico, OS Latinovic
Journal of Translational Medicine, 2022-01-24;20(1):39.
Species: Human
Sample Types: Whole Cells
Applications: ICC
A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody.
Authors: Chain B, Arnold J, Akthar S, Brandt M, Davis D, Noursadeghi M, Lapp T, Ji C, Sankuratri S, Zhang Y, Govada L, Saridakis E, Chayen N
PLoS ONE, 2015-06-01;10(6):e0128381.
Species: Human
Sample Types: Peptide, Whole Cells
Applications: ELISA Development, Flow Cytometry
Preferential recognition of monomeric CCR5 expressed in cultured cells by the HIV-1 envelope glycoprotein gp120 for the entry of R5 HIV-1.
Authors: Nakano Y, Monde K, Terasawa H, Yuan Y, Yusa K, Harada S, Maeda Y
Virology, 2014-01-31;452(0):117-24.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages.
Authors: Swaminathan G, Rossi F, Sierra L, Gupta A, Navas-Martin S, Martin-Garcia J
PLoS Pathog, 2012-09-20;8(9):e1002937.
Species: Human
Sample Types: Whole Cells
Applications: ICC
A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5.
Authors: Tilton J, Wilen C, Didigu C, Sinha R, Harrison J, Agrawal-Gamse C, Henning E, Bushman F, Martin J, Deeks S, Doms R
J Virol, 2010-08-11;84(20):10863-76.
CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2.
Authors: Ottonello L, Montecucco F, Bertolotto M, Arduino N, Mancini M, Corcione A, Pistoia V, Dallegri F
Cell. Signal., 2005-03-01;17(3):355-63.
Species: Human
Sample Types: Cell Lysates, Whole Cells
Applications: Flow Cytometry, Western Blot