Home / CCR7 / Human CCR7 Antibody

Human CCR7 Antibody

Catalog #: MAB197
89 Citations 2 Reviews Datasheet / COA / SDS
Clone 150503 was used by HLDA to establish CD designation
Catalog # Availability Size / Price Qty
MAB197-100
MAB197-SP
Detection of CCR7 in Human PBMCs by Flow Cytometry.
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Product Details
Citations (89)
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Reviews (2)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CCR7 Antibody Summary

Species Reactivity
Human
Specificity
Detects human CCR7.
Source
Monoclonal Mouse IgG2A Clone # 150503
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human CCR7 transfectants
Met1-Pro378
Accession # AAA58615
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25 µg/106 cells
See below
Immunohistochemistry
5-25 µg/mL
See below
CyTOF-reported
Mei, H.E. et al. (2015) J. Immunol. 194: 2022. Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Immunocytochemistry
8-25 µg/mL
See below
Neutralization
Measured by its ability to neutralize CCL19/MIP‑3 beta -induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CCR7. The Neutralization Dose (ND50) is typically 1-5 µg/mL in the presence of 50 ng/mL Recombinant Human CCL19/MIP‑3 beta.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CCR7 antibody in Human PBMCs antibody by Flow Cytometry. View Larger

Detection of CCR7 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD4 PE-conjugated Monoclonal Antibody (Catalog # FAB3791P) and either (A) Mouse Anti-Human CCR7 Monoclonal Antibody (Catalog # MAB197) or (B) Mouse IgG2AIsotype Control (Catalog # MAB003) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins.

Immunocytochemistry CCR7 antibody in Human PBMCs by Immunocytochemistry (ICC). View Larger

CCR7 in Human PBMCs. CCR7 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using 25 µg/mL Mouse Anti-Human CCR7 Monoclonal Antibody (Catalog # MAB197) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Immunohistochemistry CCR7 antibody in Human Lung by Immunohistochemistry (IHC-P). View Larger

CCR7 in Human Lung. CCR7 was detected in immersion fixed paraffin-embedded sections of human lung using Mouse Anti-Human CCR7 Monoclonal Antibody (Catalog # MAB197) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in macrophages. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Neutralization Chemotaxis Induced by CCL19/MIP‑3 beta and Neutral-ization by Human CCR7 Antibody. View Larger

Chemotaxis Induced by CCL19/MIP‑3 beta and Neutral-ization by Human CCR7 Antibody. Recombinant Human CCL19/MIP-3 beta (Catalog # 361-MI) chemoattracts the BaF3 mouse pro-B cell line transfected with human CCR7 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Human CCL19/MIP-3 beta (50 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human CCR7 Monoclonal Antibody (Catalog # MAB197). The ND50 is typically 1-5 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CCR7

CCR7 (Chemokine Receptor 7; also CD197) is a 7 transmembrane (7TM) G protein-coupled chemokine receptor for the homeostatic chemokines CCL19/MIP-3 beta and CCL21/6Ckine. CCL19 and CCL21 are constitutively expressed by high endothelial venule epithelial cells or fibroblastic reticular cells in secondary lymphoid organs. CCR7 is upregulated on dendritic cells, naïve and memory T cells, Treg, NK cells, and B cells following inflammatory stimulation. Its expression enables the function of immune cell trafficking to and retention in regional lymph nodes for expansion of the adaptive immune response. Human CCR7 shares 87% amino acid sequence identity with mouse CCR7.

Entrez Gene IDs
1236 (Human); 12775 (Mouse); 287673 (Rat)
Alternate Names
BLR2; BLR2C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR7; CCR-7; CD197 antigen; CD197; CDw197; CDw197CC chemokine receptor 7; chemokine (C-C motif) receptor 7; CMKBR7; CMKBR7chemokine (C-C) receptor 7; EBI1; EBI1EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus induced G-protein coupled receptor; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor

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Citations for Human CCR7 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

89 Citations: Showing 1 - 10
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  1. CCR7 Mediates Cell Invasion and Migration in Extrahepatic Cholangiocarcinoma by Inducing Epithelial-Mesenchymal Transition
    Authors: M Oba, Y Nakanishi, T Mitsuhashi, K Sasaki, KC Hatanaka, M Sasaki, A Nange, A Okumura, M Hayashi, Y Yoshida, T Nitta, T Ueno, T Yamada, M Ono, S Kuwabara, K Okamura, T Tsuchikawa, T Nakamura, T Noji, T Asano, K Tanaka, K Takayama, Y Hatanaka, S Hirano
    Cancers, 2023-03-21;15(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  2. Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection
    Authors: SA Rahman, J Billinglsl, AA Sharma, TM Styles, S Govindaraj, U Shanmugasu, H Babu, SP Ribeiro, SA Ali, GK Tharp, C Ibegbu, S Waggoner, RP Johnson, RP Sékaly, F Villinger, SE Bosinger, RR Amara, V Velu
    JCI Insight, 2022-04-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription
    Authors: AA Okoye, R Fromentin, H Takata, JH Brehm, Y Fukazawa, B Randall, M Pardons, V Tai, J Tang, J Smedley, M Axthelm, JD Lifson, LJ Picker, D Favre, L Trautmann, N Chomont
    PloS Pathogens, 2022-01-18;18(1):e1010245.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  4. Contribution of Heparan Sulphate Binding in CCL21-Mediated Migration of Breast Cancer Cells
    Authors: I Del Molino, A Meeson, K Cooke, MI Malki, B Barron-Mil, JA Kirby, S Ali
    Cancers, 2021-07-10;13(14):.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  5. Helicobacter pylori-induced Rev-erb&alpha fosters gastric bacteria colonization by impairing host innate and adaptive defense
    Authors: FY Mao, YP Lv, CJ Hao, YS Teng, YG Liu, P Cheng, SM Yang, W Chen, T Liu, QM Zou, R Xie, JY Xu, Y Zhuang
    Cellular and Molecular Gastroenterology and Hepatology, 2021-03-03;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  6. Effects of storage time and temperature on highly multiparametric flow analysis of peripheral blood samples; implications for clinical trial samples
    Authors: A Jerram, TV Guy, L Beutler, B Gunasegara, R Sluyter, B Fazekas de, HM McGuire
    Bioscience Reports, 2021-02-26;41(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: CyTof
  7. Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions
    Authors: JA van Ipenbu, NE de Waard, NC Naus, MJ Jager, D Paridaens, RM Verdijk
    Invest. Ophthalmol. Vis. Sci., 2019-07-01;60(8):2950-2957.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  8. Siglec-9 regulates an effector memory CD8+ T-cell subset that congregates in the melanoma tumor microenvironment
    Authors: Q Haas, K Frias Boli, C Jandus, C Schneider, C Simillion, MA Stanczak, M Haubitz, SM Seyed Jafa, A Zippelius, GM Baerlocher, H Läubli, RE Hunger, P Romero, HU Simon, S von Gunten
    Cancer Immunol Res, 2019-04-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound
    Authors: AA Okoye, SG Hansen, M Vaidya, Y Fukazawa, H Park, DM Duell, R Lum, CM Hughes, AB Ventura, E Ainslie, JC Ford, D Morrow, RM Gilbride, AW Legasse, J Hesselgess, R Geleziunas, Y Li, K Oswald, R Shoemaker, R Fast, WJ Bosche, BR Borate, PT Edlefsen, MK Axthelm, LJ Picker, JD Lifson
    Nat. Med., 2018-08-06;0(0):.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors
    Authors: T Alexander, Q Cheng, J Klotsche, L Khodadadi, A Waka, R Biesen, BF Hoyer, GR Burmester, A Radbruch, F Hiepe
    Eur. J. Immunol., 2018-07-30;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition
    Authors: N Jouand, C Bressollet, N Gérard, M Giral, P Guérif, A Rodallec, R Oger, T Parrot, M Allard, A Cesbron-Ga, N Gervois, B Charreau
    PLoS Pathog., 2018-04-30;14(4):e1007041.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Regulation of CCR7-dependent cell migration through�CCR7 homodimer formation
    Authors: D Kobayashi, M Endo, H Ochi, H Hojo, M Miyasaka, H Hayasaka
    Sci Rep, 2017-08-17;7(1):8536.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  13. Inducible activation of MyD88 and CD40 in CAR T-cells results in controllable and potent antitumor activity in preclinical solid tumor models
    Authors: M Mata, C Gerken, P Nguyen, G Krenciute, DM Spencer, S Gottschalk
    Cancer Discov, 2017-08-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use
    Authors: JMJ Van den Be, ELJM Smits, M Versteven, H De Reu, ZN Berneman, VFI Van Tendel, E Lion
    J Immunol Res, 2017-07-13;2017(0):1975902.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  15. Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages
    Authors: F Bellora, A Dondero, MV Corrias, B Casu, S Regis, F Caliendo, A Moretta, M Cazzola, C Elena, L Vinti, F Locatelli, C Bottino, R Castriconi
    J. Immunol., 2017-07-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. pERK-dependent defective TCR-mediated activation of CD4(+) T cells in end-stage renal disease patients
    Authors: L Huang, NHR Litjens, NM Kannegiete, M Klepper, CC Baan, MGH Betjes
    Immun Ageing, 2017-06-19;14(0):14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. Reconstitution of immune cell populations in multiple sclerosis patients after autologous stem cell transplantation
    Authors: FG Karnell, D Lin, S Motley, T Duhen, N Lim, DJ Campbell, LA Turka, HT Maecker, KM Harris
    Clin. Exp. Immunol., 2017-06-07;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: CyTof
  18. Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques
    Authors: SM Nguyen, KM Antony, DM Dudley, S Kohn, HA Simmons, B Wolfe, MS Salamat, LBC Teixeira, GJ Wiepz, TH Thoong, MT Aliota, AM Weiler, GL Barry, KL Weisgrau, LJ Vosler, MS Mohns, ME Breitbach, LM Stewart, MN Rasheed, CM Newman, ME Graham, OE Wieben, PA Turski, KM Johnson, J Post, JM Hayes, N Schultz-Da, ML Schotzko, JA Eudailey, SR Permar, EG Rakasz, EL Mohr, S Capuano, AF Tarantal, JE Osorio, SL O'Connor, TC Friedrich, DH O'Connor, TG Golos
    PLoS Pathog., 2017-05-25;13(5):e1006378.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  19. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck
    Authors: Z Zhang, F Liu, Z Li, D Wang, R Li, C Sun
    Oncol Lett, 2017-03-14;13(5):3191-3197.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Neutralization
  20. Interferon-?-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathway-mediated Killer Activity
    Authors: T Koya, R Yanagisawa, Y Higuchi, K Sano, S Shimodaira
    Sci Rep, 2017-02-13;7(0):42145.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  21. Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset
    Authors: J Dunham, N van Driel, BJ Eggen, C Paul, BA 't Hart, JD Laman, YS Kap
    Clin Transl Immunology, 2017-02-10;6(2):e127.
    Species: Primate
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  22. Chemoprophylaxis with sporozoite immunization in P. knowlesi rhesus monkeys confers protection and elicits sporozoite-specific memory T cells in the liver
    Authors: S Pichyangku, MD Spring, K Yongvanitc, U Kum-Arb, A Limsalakpe, R Im-Erbsin, R Ubalee, P Vanachayan, EJ Remarque, E Angov, PL Smith, DL Saunders
    PLoS ONE, 2017-02-09;12(2):e0171826.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  23. Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction
    Nat Commun, 2016-12-23;7(0):13895.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  24. NFKB1 regulates human NK cell maturation and effector functions
    Authors: Vassilios Lougaris
    Clin. Immunol, 2016-12-03;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  25. Optimization of mass cytometry sample cryopreservation after staining
    Authors: Evan W Newell
    Cytometry A, 2016-10-31;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: CyTof
  26. Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs
    PLoS Pathog, 2016-08-19;12(8):e1005799.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  27. Dengue virus infection induces interferon-lambda1 to facilitate cell migration
    Sci Rep, 2016-07-26;6(0):24530.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  28. Differences in expression of gut-homing receptors on CD4+ T cells in black and white HIV-negative men who have sex with men
    Authors: CF Kelley, L Lai, C Ibegbu, ES Rosenberg, S Kaur, K Patel, MJ Mulligan, VC Marconi, PS Sullivan, RR Amara
    AIDS, 2016-05-15;30(8):1305-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  29. Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5
    J Immunol, 2016-05-13;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  30. Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.
    Authors: Okoye A, Rohankhedkar M, Konfe A, Abana C, Reyes M, Clock J, Duell D, Sylwester A, Sammader P, Legasse A, Park B, Axthelm M, Nikolich-Zugich J, Picker L
    J Immunol, 2015-09-28;195(9):4292-305.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  31. Tissue Distribution of Memory T and B Cells in Rhesus Monkeys following Influenza A Infection.
    Authors: Pichyangkul S, Yongvanitchit K, Limsalakpetch A, Kum-Arb U, Im-Erbsin R, Boonnak K, Thitithayanont A, Jongkaewwattana A, Wiboon-ut S, Mongkolsirichaikul D, Mahanonda R, Spring M, Chuang I, Mason C, Saunders D
    J Immunol, 2015-09-25;195(9):4378-86.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  32. Trypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype.
    Authors: White M, Gomer R
    PLoS ONE, 2015-09-25;10(9):e0138748.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  33. Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia.
    Authors: Patrussi L, Capitani N, Martini V, Pizzi M, Trimarco V, Frezzato F, Marino F, Semenzato G, Trentin L, Baldari C
    Cancer Res, 2015-08-17;75(19):4153-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  34. Evidence for eomesodermin-expressing innate-like CD8(+) KIR/NKG2A(+) T cells in human adults and cord blood samples.
    Authors: Jacomet F, Cayssials E, Basbous S, Levescot A, Piccirilli N, Desmier D, Robin A, Barra A, Giraud C, Guilhot F, Roy L, Herbelin A, Gombert J
    Eur J Immunol, 2015-05-20;45(7):1926-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  35. Uptake of CCR7 by KIR2DS4(+) NK cells is induced upon recognition of certain HLA-C alleles.
    Authors: Pesce S, Carlomagno S, Moretta A, Sivori S, Marcenaro E
    J Immunol Res, 2015-04-16;2015(0):754373.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  36. Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry.
    Authors: Mei H, Leipold M, Schulz A, Chester C, Maecker H
    J Immunol, 2015-01-21;194(4):2022-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: CyTof
  37. Prognostic markers for patient outcome following vaccination with multiple MHC Class I/II-restricted WT1 peptide-pulsed dendritic cells plus chemotherapy for pancreatic cancer.
    Authors: Takakura K, Koido S, Kan S, Yoshida K, Mori M, Hirano Y, Ito Z, Kobayashi H, Takami S, Matsumoto Y, Kajihara M, Misawa T, Okamoto M, Sugiyama H, Homma S, Ohkusa T, Tajiri H
    Anticancer Res, 2015-01-01;35(1):555-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  38. Cytokine production and antigen recognition by human mucosal homing conjunctival effector memory CD8+ T cells.
    Authors: Williams G, Pachnio A, Long H, Rauz S, Curnow S
    Invest Ophthalmol Vis Sci, 2014-11-13;55(12):8523-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  39. The chemotaxis of M1 and M2 macrophages is regulated by different chemokines.
    Authors: Xuan W, Qu Q, Zheng B, Xiong S, Fan G
    J Leukoc Biol, 2014-10-30;97(1):61-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  40. Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression.
    Authors: Schanz A, Red-Horse K, Hess A, Baston-Bust D, Heiss C, Krussel J
    Placenta, 2014-09-26;35(12):1089-94.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  41. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
    Authors: Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
    Nat Commun, 2014-09-02;5(0):4715.
    Species: Human
    Sample Types: Whole Cells
    Applications: Blocking
  42. Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.
    Authors: Antsiferova O, Muller A, Ramer P, Chijioke O, Chatterjee B, Raykova A, Planas R, Sospedra M, Shumilov A, Tsai M, Delecluse H, Munz C
    PLoS Pathog, 2014-08-28;10(8):e1004333.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  43. The MEC1 and MEC2 lines represent two CLL subclones in different stages of progression towards prolymphocytic leukemia.
    Authors: Rasul E, Salamon D, Nagy N, Leveau B, Banati F, Szenthe K, Koroknai A, Minarovits J, Klein G, Klein E
    PLoS ONE, 2014-08-27;9(8):e106008.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  44. Proteome-wide analysis of HIV-specific naive and memory CD4(+) T cells in unexposed blood donors.
    Authors: Campion S, Brodie T, Fischer W, Korber B, Rossetti A, Goonetilleke N, McMichael A, Sallusto F
    J Exp Med, 2014-06-23;211(7):1273-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  45. Priming by chemokines restricts lateral mobility of the adhesion receptor LFA-1 and restores adhesion to ICAM-1 nano-aggregates on human mature dendritic cells.
    Authors: Borgman K, van Zanten T, Manzo C, Cabezon R, Cambi A, Benitez-Ribas D, Garcia-Parajo M
    PLoS ONE, 2014-06-19;9(6):e99589.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  46. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15.
    Authors: Xu Y, Zhang M, Ramos C, Durett A, Liu E, Dakhova O, Liu H, Creighton C, Gee A, Heslop H, Rooney C, Savoldo B, Dotti G
    Blood, 2014-04-29;123(24):3750-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry (CAR-T)
  47. CD20+ B cell depletion alters T cell homing.
    Authors: Kap, Yolanda, van Driel, Nikki, Laman, Jon D, Tak, Paul P, 't Hart, Bert A
    J Immunol, 2014-04-02;192(9):4242-53.
    Species: Marmoset
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  48. CD56(bright)perforin(low) noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph.
    Authors: Carrega, Paolo, Bonaccorsi, Irene, Di Carlo, Emma, Morandi, Barbara, Paul, Petra, Rizzello, Valeria, Cipollone, Giuseppe, Navarra, Giuseppe, Mingari, Maria Cr, Moretta, Lorenzo, Ferlazzo, Guido
    J Immunol, 2014-03-19;192(8):3805-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  49. Development and function of human innate immune cells in a humanized mouse model.
    Authors: Rongvaux, Anthony, Willinger, Tim, Martinek, Jan, Strowig, Till, Gearty, Sofia V, Teichmann, Lino L, Saito, Yasuyuki, Marches, Florenti, Halene, Stephani, Palucka, A Karoli, Manz, Markus G, Flavell, Richard
    Nat Biotechnol, 2014-03-16;32(4):364-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  50. Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
    Authors: Pinto S, Martinez-Romero A, O'Connor J, Gil-Benso R, San-Miguel T, Terradez L, Monteagudo C, Callaghan R
    BMC Cancer, 2014-02-22;14(0):118.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  51. Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node.
    Authors: Yin X, Johns S, Kim D, Mikulski Z, Salanga C, Handel T, Macal M, Zuniga E, Fuster M
    J Immunol, 2014-02-03;192(5):2133-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Blocking
  52. Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients with advanced cancer.
    Authors: Ishikawa, Takeshi, Kokura, Satoshi, Enoki, Tatsuji, Sakamoto, Naoyuki, Okayama, Tetsuya, Ideno, Mitsuko, Mineno, Junichi, Uno, Kazuko, Yoshida, Naohisa, Kamada, Kazuhiro, Katada, Kazuhiro, Uchiyama, Kazuhiko, Handa, Osamu, Takagi, Tomohisa, Konishi, Hideyuki, Yagi, Nobuaki, Naito, Yuji, Itoh, Yoshito, Yoshikawa, Toshikaz
    PLoS ONE, 2014-01-31;9(1):e83786.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  53. Anti-CCR7 therapy exerts a potent anti-tumor activity in a xenograft model of human mantle cell lymphoma.
    Authors: Somovilla-Crespo B, Alfonso-Perez M, Cuesta-Mateos C, Carballo-de Dios C, Beltran A, Terron F, Perez-Villar J, Gamallo-Amat C, Perez-Chacon G, Fernandez-Ruiz E, Zapata J, Munoz-Calleja C
    J Hematol Oncol, 2013-12-04;6(0):89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  54. Neuroblastoma-derived TGF-beta1 modulates the chemokine receptor repertoire of human resting NK cells.
    Authors: Castriconi R, Dondero A, Bellora F, Moretta L, Castellano A, Locatelli F, Corrias M, Moretta A, Bottino C
    J Immunol, 2013-04-10;190(10):5321-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  55. TCR-driven transendothelial migration of human effector memory CD4 T cells involves Vav, Rac, and myosin IIA.
    Authors: Manes, Thomas D, Pober, Jordan S
    J Immunol, 2013-02-18;190(7):3079-88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Functional Assay
  56. IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells.
    Authors: Santegoets S, Turksma A, Suhoski M, Stam A, Albelda S, Hooijberg E, Scheper R, van den Eertwegh A, Gerritsen W, Powell D, June C, de Gruijl T
    J Transl Med, 2013-02-12;11(0):37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  57. Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency.
    Authors: Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A
    J Allergy Clin Immunol, 2013-02-10;131(4):1146-56, 1156.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  58. NK cells from malignant pleural effusions are not anergic but produce cytokines and display strong antitumor activity on short-term IL-2 activation.
    Authors: Vacca P, Martini S, Garelli V, Passalacqua G, Moretta L, Mingari M
    Eur J Immunol, 2013-01-15;43(2):550-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  59. Functional diversity of human vaginal APC subsets in directing T-cell responses.
    Authors: Duluc, D, Gannevat, J, Anguiano, E, Zurawski, S, Carley, M, Boreham, M, Stecher, J, Dullaers, M, Banchereau, J, Oh, S
    Mucosal Immunol, 2012-11-07;6(3):626-38.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Flow Cytometry
  60. Accelerated heterologous adenovirus prime-boost SIV vaccine in neonatal rhesus monkeys.
    Oncogene, 2012-05-16;86(15):7829-35.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  61. Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta.
    Authors: Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F
    Nature, 2012-04-26;484(7395):514-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  62. Identification of human NK17/NK1 cells.
    Authors: Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA
    PLoS ONE, 2011-10-21;6(10):e26780.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  63. Early Induction of Polyfunctional Simian Immunodeficiency Virus (SIV)-Specific T Lymphocytes and Rapid Disappearance of SIV from Lymph Nodes of Sooty Mangabeys during Primary Infection.
    Authors: Meythaler M, Wang Z, Martinot A, Pryputniewicz S, Kasheta M, McClure HM, O'Neil SP, Kaur A
    J. Immunol., 2011-03-25;186(9):5151-61.
    Species: Primate - Cercocebus torquatus (Sooty Mangabey)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  64. Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.
    Authors: Islam SA, Chang DS, Colvin RA
    Nat. Immunol., 2011-01-09;12(2):167-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  65. Blocking of alpha4beta7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques.
    Authors: Ansari AA, Reimann KA, Mayne AE, Takahashi Y, Stephenson ST, Wang R, Wang X, Li J, Price AA, Little DM, Zaidi M, Lyles R, Villinger F
    J. Immunol., 2010-12-13;186(2):1044-59.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  66. Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome.
    Authors: Antonelli LR, Mahnke Y, Hodge JN, Porter BO, Barber DL, DerSimonian R, Greenwald JH, Roby G, Mican J, Sher A, Roederer M, Sereti I
    Blood, 2010-07-26;116(19):3818-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  67. Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones in rhesus macaques during acute infection.
    Authors: Minang JT, Trivett MT, Bolton DL, Trubey CM, Estes JD, Li Y, Smedley J, Pung R, Rosati M, Jalah R, Pavlakis GN, Felber BK, Piatak M, Roederer M, Lifson JD, Ott DE, Ohlen C
    J. Immunol., 2009-11-30;184(1):315-26.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  68. Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques.
    Authors: Bolton DL, Minang JT, Trivett MT, Song K, Tuscher JJ, Li Y, Piatak M, O'Connor D, Lifson JD, Roederer M, Ohlen C
    J. Immunol., 2009-11-30;184(1):303-14.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  69. CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets.
    Authors: Yu J, Mao HC, Wei M, Hughes T, Zhang J, Park IK, Liu S, McClory S, Marcucci G, Trotta R, Caligiuri MA
    Blood, 2009-11-06;115(2):274-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  70. CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia.
    Authors: Berrih-Aknin S, Ruhlmann N, Bismuth J, Cizeron-Clairac G, Zelman E, Shachar I, Dartevelle P, de Rosbo NK, Le Panse R
    Ann. Neurol., 2009-10-01;66(4):521-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  71. Expression of podoplanin and other lymphatic markers in the human anterior eye segment.
    Authors: Birke K, Lutjen-Drecoll E, Kerjaschki D, Birke MT
    Invest. Ophthalmol. Vis. Sci., 2009-09-08;51(1):344-54.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  72. Post-apoptotic tumors are more palatable to dendritic cells and enhance their antigen cross-presentation activity.
    Authors: Brusa D, Garetto S, Chiorino G, Scatolini M, Migliore E, Camussi G, Matera L
    Vaccine, 2008-10-09;26(50):6422-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  73. RNA-loaded CD40-activated B cells stimulate antigen-specific T-cell responses in dogs with spontaneous lymphoma.
    Authors: Mason NJ, Coughlin CM, Overley B, Cohen JN, Mitchell EL, Colligon TA, Clifford CA, Zurbriggen A, Sorenmo KU, Vonderheide RH
    Gene Ther., 2008-03-13;15(13):955-65.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  74. Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2 T cells in macaques.
    Authors: Ali Z, Shao L, Halliday L, Reichenberg A, Hintz M, Jomaa H, Chen ZW
    J. Immunol., 2007-12-15;179(12):8287-96.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  75. Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression.
    Authors: Yamanaka K, Dimitroff CJ, Fuhlbrigge RC, Kakeda M, Kurokawa I, Mizutani H, Kupper TS
    J. Allergy Clin. Immunol., 2007-10-01;121(1):148-157.e3.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  76. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.
    Authors: Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH
    J. Immunol., 2007-09-15;179(6):3724-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  77. Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
    Authors: Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ
    J. Exp. Med., 2007-08-27;204(9):2171-85.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  78. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling.
    Authors: Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA
    Cancer Cell, 2007-06-01;11(6):526-38.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells, Whole Tissue
    Applications: IHC, Neutralization, Western Blot
  79. Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.
    Authors: Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM
    Am. J. Pathol., 2007-04-01;170(4):1152-64.
    Species: Complex Species Category
    Sample Types: Complex Sample Type
    Applications: Neutralization
  80. Transduction with human telomerase reverse transcriptase immortalizes a rhesus macaque CD8+ T cell clone with maintenance of surface marker phenotype and function.
    Authors: Andersen H, Barsov EV, Trivett MT, Trubey CM, Giavedoni LD, Lifson JD, Ott DE, Ohlen C
    AIDS Res. Hum. Retroviruses, 2007-03-01;23(3):456-65.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  81. Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21.
    Authors: Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Evanoff H, Flaherty KR, Martinez FJ, Toews GB, Hogaboam CM
    Eur. Respir. J., 2007-03-01;29(6):1082-93.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  82. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.
    Authors: Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS
    J. Immunol., 2006-10-01;177(7):4488-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  83. The monoclonal antibody CHO-131 identifies a subset of cutaneous lymphocyte-associated antigen T cells enriched in P-selectin-binding cells.
    Authors: Ni Z, Campbell JJ, Niehans G, Walcheck B
    J. Immunol., 2006-10-01;177(7):4742-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  84. Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
    Authors: Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K, Franken-Kunkel P, Poremba C, Snyderman C, Klotz LO, Ruzicka T, Bier H, Zlotnik A, Whiteside TL, Homey B, Hoffmann TK
    Int. J. Cancer, 2006-05-01;118(9):2147-57.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  85. Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi.
    Authors: Humphreys TL, Baldridge LA, Billings SD, Campbell JJ, Spinola SM
    Infect. Immun., 2005-07-01;73(7):3896-902.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  86. Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression.
    Authors: Birebent B, Lorho R, Lechartier H, de Guibert S, Alizadeh M, Vu N, Beauplet A, Robillard N, Semana G
    Eur. J. Immunol., 2004-12-01;34(12):3485-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  87. Classification of distinct subtypes of peripheral T-cell lymphoma unspecified, identified by chemokine and chemokine receptor expression: Analysis of prognosis.
    Authors: Ohshima K, Karube K, Kawano R, Tsuchiya T, Suefuji H, Yamaguchi T, Suzumiya J, Kikuchii M
    Int. J. Oncol., 2004-09-01;25(3):605-13.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  88. Developing neonatal rabbit appendix, a primary lymphoid organ, is seeded by immature blood-borne B cells: evidence for roles for CD62L/PNAd, CCR7/CCL21, alpha4beta1 and LFA-1.
    Authors: Sinha RK, Mage RG
    Dev. Comp. Immunol., 2004-06-01;28(7):829-41.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  89. Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.
    Authors: Doubrovina ES, Doubrovin MM, Vider E, Sisson RB, O&amp;apos;Reilly RJ, Dupont B, Vyas YM
    J. Immunol., 2003-12-15;171(12):6891-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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