Human CD11c APC-conjugated Antibody

Catalog #: FAB1777A
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB1777A-100
FAB1777A-025

Detection of CD11c in Human PBMCs by Flow Cytometry.

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All CD11c Antibodies

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Citations (1)

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CD11c APC-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human CD11c.

Source

Monoclonal Mouse IgG₁ Clone # ICRF 3.9

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Rheumatoid synovial fluid cells and human monocyte-derived fibronectin

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of CD11c in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD14 PE-conjugated Monoclonal Antibody (Catalog # FAB3832P) and either (A) Mouse Anti-Human CD11c APC-conjugated Monoclonal Antibody (Catalog # FAB1777A) or (B) Mouse IgG₁Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: CD11c

Integrin alpha X, also known as CD11c, heterodimerizes with Integrin beta 2, also known as CD18. The CD11c/CD18 complex binds fibrinogen and has been reported to be a receptor for iC3b (1‑3) .

References

Hogg, N. et al. (1986) Eur. J. Immunol. 16(3):240.
Knapp, W.B. et al. eds. (1989) Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York.
Stacker, S.A. and T.A. Springer, J. Immunol. (1991) 146(2):648.

Entrez Gene IDs

3687 (Human); 16411 (Mouse); 64350 (Rat)

Alternate Names

95 alpha chain; 95; 95, alpha subunit; CD11 antigen-like family member C; CD11c antigen; CD11c; CD11Cleu M5, alpha subunit; Integrin alpha X; integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); ITGAX; Leu M5; Leukocyte adhesion glycoprotein p150; Leukocyte adhesion receptor p150; leukocyte surface antigen p150; myeloid membrane antigen, alpha subunit; p150 95 integrin alpha chain; p150,95 alpha; SLEB6

Product Datasheets

Product Datasheet

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Related Research Areas

Citation for Human CD11c APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
Authors: Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R
Clin Cancer Res, 2013-02-26;19(7):1858-72.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry