Human CRHR-1 Antibody

Catalog #: MAB3930
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB3930
MAB3930-SP

All CRHR1 Antibodies

Product Details

Citations (1)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CRHR-1 Antibody Summary

Species Reactivity

Human

Specificity

Detects human CRHR‑1 transfectants but not irrelevant transfectants.

Source

Monoclonal Mouse IgG_2A Clone # 343919

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

NS0 mouse myeloma cell line transfected with human CRHR-1
Ser24-Val415
Accession # NP_004373

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Purity

Protein A or G purified from hybridoma culture supernatant

Applications

Recommended Concentration

Sample

Flow Cytometry

2.5 µg/10⁶ cells

Human CRHR‑1 transfected Ba/F3 cells

Immunohistochemistry

8-25 µg/mL

Immersion fixed paraffin-embedded sections of human placenta

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CRHR1

Corticotrophin-Releasing Hormone Receptor 1 (CRHR-1), also known as CRFR-1, is a 7TM protein that belongs to the G protein-coupled receptor family 2. CRHR-1 is expressed in the brain and adrenal gland where it mediates corticotropin-induced effects on anxiety, depression, and stress-associated pathologies. The immunogen for this antibody corresponds to one of the four alternately spliced forms and has a 29 amino acid deletion in the first cytoplasmic domain. Human CRHR-1 shares 97% amino acid sequence identity with mouse and rat CRHR-1.

Long Name

Corticotropin Releasing Hormone Receptor 1

Entrez Gene IDs

1394 (Human); 12921 (Mouse)

Alternate Names

CHR-R1; corticotropin releasing hormone receptor 1; corticotropin-releasing factor receptor 1; corticotropin-releasing factor type 1 receptor; Corticotropin-releasing hormone receptor 1; CRF1; CRFR; CRF-R; CRFR1; CRF-R1; CRF-R-1; CRFR-1; CRHR1; CRH-R-1; CRHR1f; CRH-R1h; CRHR1L; CRHRCRH-R1; seven transmembrane helix receptor

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citation for Human CRHR-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1