Home / CTGF/CCN2 / Human CTGF/CCN2 C-Terminus Antibody

Human CTGF/CCN2 C-Terminus Antibody

Catalog #: MAB660
6 Citations 4 Reviews Datasheet / COA / SDS
C-terminal Peptide
Catalog # Availability Size / Price Qty
MAB660-SP
MAB660-500
MAB660-100
CTGF/CCN2 in Human Breast Cancer Tissue.
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Product Details
Citations (6)
FAQs
Supplemental Products
Reviews (4)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CTGF/CCN2 C-Terminus Antibody Summary

Species Reactivity
Human
Specificity
Detects human CTGF C-teriminal peptide in direct ELISAs. Does not cross-react with recombinant human (rh) LDGF, rhNOV, rhPDGF, rhPlGF, rhVEGF206, rhVEGF-B186, rhVEGF-C, rhVEGF-D, or rhWISP-1.
Source
Monoclonal Mouse IgG1 Clone # 88430
Purification
Protein A or G purified from ascites
Immunogen
E. coli-derived recombinant human CTGF
Glu247-Ala349
Accession # NP_001892.1
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Purity
Protein A or G purified from ascites

Applications

Recommended Concentration
Sample
Immunohistochemistry
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry CTGF/CCN2 antibody in Human Breast Cancer Tissue by Immunohistochemistry (IHC-P). View Larger

CTGF/CCN2 in Human Breast Cancer Tissue. CTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 25 µg/mL Human CTGF/CCN2 C-Terminus Monoclonal Antibody (Catalog # MAB660) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CTGF/CCN2

CTGF belongs to the CCN (CYR61/CTGF/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains IGF-binding protein domain, a von Willebrand factor type C domain, a thrombospondin type I domain, and a cysteine knot domain. The multimodular CTGF has the ability to bind multiple ligands and has numerous effects on development, differentation, and disease. The C-terminal cysteine knot motif contains the heparin and low density lipoprotein receptor (LDLR) binding sites that contributes to the adhesive and mitogenic properties of CTGF.

Long Name
Connective Tissue Growth Factor
Entrez Gene IDs
1490 (Human); 14219 (Mouse); 64032 (Rat)
Alternate Names
CCN2; CCN2IGFBP-8; connective tissue growth factor; CTGF; CTGRP; Fisp12; HCS24; Hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP-8; IGFBP8CCN family member 2; Insulin-like growth factor-binding protein 8; MGC102839; NOV2

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Citations for Human CTGF/CCN2 C-Terminus Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Curcumin inhibits TGF-?1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts
    Authors: JT Chen, CY Wang, MH Chen
    J. Formos. Med. Assoc., 2018-01-17;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  2. Human gingiva transcriptome during wound healing
    Authors: Yun Wang
    J. Clin. Periodontol, 2017-02-11;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  3. Anti-CTGF single-chain variable fragment dimers inhibit human airway smooth muscle (ASM) cell proliferation by down-regulating p-Akt and p-mTOR levels.
    Authors: Gao W, Cai L, Xu X, Fan J, Xue X, Yan X, Qu Q, Wang X, Zhang C, Wu G
    PLoS ONE, 2014-12-05;9(12):e113980.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Development
  4. A physiological role for connective tissue growth factor in early wound healing.
    Authors: Alfaro, Maria P, Deskins, Desirae, Wallus, Meredith, DasGupta, Jayasri, Davidson, Jeffrey, Nanney, Lillian, A Guney, Michelle, Gannon, Maureen, Young, Pampee P
    Lab Invest, 2012-11-19;93(1):81-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway.
    Authors: Chen, Pai-Shen, Wang, Ming-Yan, Wu, Shin-Ni, Su, Jen-Lian, Hong, Chih-Che, Chuang, Shuang-E, Chen, Min-Wei, Hua, Kuo-Tai, Wu, Yu-Ling, Cha, Shih-Tin, Babu, Munisamy, Chen, Chiung-N, Lee, Po-Huang, Chang, King-Jen, Kuo, Min-Lian
    J Cell Sci, 2007-06-15;120(0):2053-65.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.
    Authors: Gronborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A, Pandey A
    Mol. Cell Proteomics, 2005-10-08;5(1):157-71.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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Reviews for Human CTGF/CCN2 C-Terminus Antibody

Average Rating: 4.3 (Based on 4 Reviews)

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Human CTGF/CCN2 C-Terminus Antibody
By Anonymous on 06/10/2020
Application: Microarrays Sample Tested: EDTA Plasma Species: Human
Other Human CTGF/CCN2 C-Terminus Antibody MAB660
Human CTGF/CCN2 C-Terminus Antibody
By Anonymous on 11/20/2018
Application: MiAr Sample Tested: EDTA Plasma Species: Human
Human CTGF/CCN2 C-Terminus Antibody
By Anonymous on 11/11/2018
Application: ELISA Sample Tested: Serum and Plasma Species: Human
Human CTGF/CCN2 C-Terminus Antibody
By Anonymous on 11/07/2018
Application: Microarrays Sample Tested: EDTA Plasma Species: Human