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Human CXCR4 Antibody

Catalog #: MAB172
55 Citations 4 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB172-100
MAB172-SP
Detection of CXCR4 in Jurkat Human Cell Line by Flow Cytometry.
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Product Details
Citations (55)
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Supplemental Products
Reviews (4)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CXCR4 Antibody Summary

Species Reactivity
Human
Specificity
Detects human CXCR4. It will also react with cells expressing feline CXCR4 but not rat CXCR4.
Source
Monoclonal Mouse IgG2B Clone # 44716
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
3T3 cells transfected with human CXCR4
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25 µg/106 cells
See below
Immunohistochemistry
8-25 µg/mL
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Neutralization
Measured by its ability to neutralize CXCL12/SDF‑1 alpha -induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CXCR4. The Neutralization Dose (ND50) is typically 2.5-12 µg/mL in the presence of 1 ng/mL Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CXCR4 antibody in Jurkat Human Cell Line antibody by Flow Cytometry. View Larger

Detection of CXCR4 in Jurkat Human Cell Line by Flow Cytometry. Jurkat human acute T cell leukemia cell line was stained with Mouse Anti-Human CXCR4 Monoclonal Antibody (Catalog # MAB172, filled histogram) or isotype control antibody (Catalog # MAB004, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins.

Immunohistochemistry CXCR4 antibody in Human Lymph Node by Immunohistochemistry (IHC-P). View Larger

CXCR4 in Human Lymph Node. CXCR4 was detected in immersion fixed paraffin-embedded sections of human lymph node using 15 µg/mL Human CXCR4 Monoclonal Antibody (Catalog # MAB172) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-AEC Cell & Tissue Staining Kit (red; Catalog # CTS003) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Immunohistochemistry CXCR4 antibody in Human Spleen by Immunohistochemistry (IHC-P). View Larger

CXCR4 in Human Spleen. CXCR4 was detected in immersion fixed paraffin-embedded sections of human spleen using Mouse Anti-Human CXCR4 Monoclonal Antibody (Catalog # MAB172) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm and nuclei. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Neutralization Chemotaxis Induced by CXCL12/SDF‑1 alpha and Neutralization by Human CXCR4 Antibody. View Larger

Chemotaxis Induced by CXCL12/SDF‑1 alpha and Neutralization by Human CXCR4 Antibody. Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF-1a (Catalog # 350-NS) chemoattracts the BaF3 mouse pro-B cell line transfected with human CXCR4 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF-1a (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human CXCR4 Monoclonal Antibody (Catalog # MAB172). The ND50 is typically 2.5-12 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CXCR4

CXCR4, also known as CD184, is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells. While primarily a membrane protein, CXCR4 undergoes trafficking and internalization in response to stimulation with phorbol esters and ligand (1). Cytoplasmic and nuclear localization of CXCR4 has been observed in colorectal and renal carcinomas (2,3) and it has been used as the basis of prognosis and metastatic state (3,4,5).

References
  1. Orsini, M.J. et al. (1999) J. Biol. Chem. 274:31076.
  2. Zagzag, D. et al. (2005) Cancer Res. 65:6178.
  3. Speetjens, F.M. et al. (2009) Cancer Microenvironment 2:1.
  4. Wang, L. et al. (2009) Oncology Reports 22:1333.
  5. Amara, S. et al. (2015) Cancer Biomark. 15:869.
Long Name
C-X-C Motif Chemokine Receptor 4
Entrez Gene IDs
7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)
Alternate Names
CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXCR4; CXC-R4; CXCR-4; D2S201E; D2S201ESDF-1 receptor; FB22; Fusin; HM89; HM89NPYRL; HSY3RR; LAP3; LAP-3; LCR1; LESTR; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3R; NPY3RWHIM; NPYR; NPYRL; NPYY3R; pCXCR4; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor; WHIMS

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Citations for Human CXCR4 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

55 Citations: Showing 1 - 10
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  1. CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients
    Authors: C D'Alterio, A Giardino, G Scognamigl, G Butturini, L Portella, G Guardascio, I Frigerio, M Montella, S Gobbo, G Martignoni, V Napolitano, F De Vita, F Tatangelo, R Franco, S Scala
    Cells, 2022-10-22;11(21):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  2. Analysis of the chemotactic factors for tumor-infiltrating fibrocytes and their prognostic significances in lung cancer
    Authors: M Tobiume, A Mitsuhashi, A Saijo, H Ogino, T Afroj, H Ogawa, H Goto, S Sato, A Abe, K Haji, R Ozaki, H Takizawa, Y Nishioka
    Oncology Letters, 2022-09-30;24(5):417.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  3. Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients
    Authors: C D'Alterio, A Spina, L Arenare, P Chiodini, M Napolitano, F Galdiero, L Portella, V Simeon, S Signoriell, F Raspaglies, D Lorusso, C Pisano, N Colombo, GF Zannoni, NS Losito, R De Cecio, G Scognamigl, D Califano, D Russo, V Tuninetti, MC Piccirillo, P Gargiulo, F Perrone, S Pignata, S Scala
    Cancers, 2022-04-06;14(7):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  4. Combination of IDO1high and CCL19low expression in the tumor tissue reduces survival in HPV positive cervical cancer
    Authors: H Jayakumar, A Seetharama, S Sunder Sin, H Dhandapani, J Subramani, S Ganeshraja, R Thangaraja, P Ramanathan
    Journal of reproductive immunology, 2021-11-23;149(0):103454.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  5. Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells.
    Authors: Wellemans V, Benhassou H, Fuselier E, Bellesort F, Dury S, Lebargy F, Dormoy V, Fichel C, Naour R, Gounni A, Lamkhioued B
    iScience, 2021-11-14;24(12):103433.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis
    Authors: M Armani-Tou, Z Zhou, R Gasser, I Staropoli, V Cantaloube, Y Benureau, J Garcia-Per, M Pérez-Olme, V Lorin, B Puissant-L, L Assoumou, C Delaugerre, JD Lelièvre, Y Lévy, H Mouquet, G Martin-Blo, J Alcami, F Arenzana-S, J Izopet, P Colin, B Lagane
    PloS Pathogens, 2021-04-19;17(4):e1009526.
    Species: Human
    Sample Types: Whole Cells
    Applications: Binding Assay
  7. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease
    Authors: A McQuade, YJ Kang, J Hasselmann, A Jairaman, A Sotelo, M Coburn, SK Shabestari, JP Chadarevia, G Fote, CH Tu, E Danhash, J Silva, E Martinez, C Cotman, GA Prieto, LM Thompson, JS Steffan, I Smith, H Davtyan, M Cahalan, H Cho, M Blurton-Jo
    Nat Commun, 2020-10-23;11(1):5370.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  8. Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma
    Authors: D Liu, A Steins, R Klaassen, AP van der Za, RJ Bennink, G van Tienho, MG Besselink, MF Bijlsma, HWM van Laarho
    Biomedicines, 2020-10-22;8(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling
    Authors: J Zheng, D Qu, C Wang, L Ding, W Zhou
    BMC Pregnancy Childbirth, 2020-02-10;20(1):87.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC, Neutralization
  10. High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma
    Authors: Q Zhu, R Luo, J Gu, Y Hou, Z Chen, F Xu, L Wang, W Mao, C Lu, D Ge
    J Cancer, 2020-01-01;11(4):810-818.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  11. Clinicopathologic determinants of pathologic treatment response in neoadjuvant treated rectal adenocarcinoma
    Authors: I González, PS Bauer, WC Chapman, Z Alipour, R Rais, J Liu, D Chatterjee
    Ann Diagn Pathol, 2019-12-14;45(0):151452.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  12. Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions
    Authors: JA van Ipenbu, NE de Waard, NC Naus, MJ Jager, D Paridaens, RM Verdijk
    Invest. Ophthalmol. Vis. Sci., 2019-07-01;60(8):2950-2957.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  13. Clinical impact of different exosomes' protein expression in pancreatic ductal carcinoma patients treated with standard first line palliative chemotherapy
    Authors: R Giampieri, F Piva, G Occhipinti, A Bittoni, A Righetti, S Pagliarett, A Murrone, F Bianchi, C Amantini, M Giulietti, G Ricci, G Principato, G Santoni, R Berardi, S Cascinu
    PLoS ONE, 2019-05-02;14(5):e0215990.
    Species: Human
    Sample Types: Plasma
    Applications: ELISA Detection
  14. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12
    Authors: I Del Molino, GC Wilkins, A Meeson, S Ali, JA Kirby
    Int J Mol Sci, 2018-11-14;19(11):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  15. Senescent fibroblasts drive ageing pigmentation: ?A potential therapeutic target for senile lentigo
    Authors: JE Yoon, Y Kim, S Kwon, M Kim, YH Kim, JH Kim, TJ Park, HY Kang
    Theranostics, 2018-09-09;8(17):4620-4632.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-P
  16. Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice
    Authors: MJ Chau, TC Deveau, X Gu, YS Kim, Y Xu, SP Yu, L Wei
    BMC Neurosci, 2018-04-12;19(1):20.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  17. Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma
    Authors: Y Kitawaki, Y Nakamura, F Kubota-Nak, Y Yamazaki, Y Miki, S Hata, K Ise, K Kikuchi, R Morimoto, F Satoh, H Sasano
    Hum. Pathol., 2018-03-27;0(0):.
    Species: Human
    Sample Types: WholeTissue
    Applications: IHC-P
  18. Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema
    Authors: W Tang, Y Chen, X Wang, Y Chen, J Zhang, Z Lin
    Oncol Lett, 2017-12-08;15(2):2501-2507.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  19. Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer
    Authors: J Zhang, C Liu, X Mo, H Shi, S Li
    Oncol Lett, 2017-12-05;15(2):1771-1776.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  20. Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth
    Authors: M Fareh, F Almairac, L Turchi, F Burel-Vand, P Paquis, D Fontaine, S Lacas-Gerv, MP Junier, H Chneiweiss, T Virolle
    Cell Death Dis, 2017-03-30;8(3):e2713.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  21. Cathepsin K cleavage of SDF-1? inhibits its chemotactic activity towards glioblastoma stem-like cells
    Authors: Vashendriya V V Hira
    Biochim. Biophys. Acta, 2016-12-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  22. The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1
    Authors: L Liu, W Wang, J Matz, C Ye, L Bracq, J Delon, JT Kimata, Z Chen, S Benichou, P Zhou
    J. Virol., 2016-11-14;90(23):10642-10659.
    Species: Human
    Sample Types: Whole Cells
    Applications: Functional Assay
  23. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices
    Proc Natl Acad Sci USA, 2016-08-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC-Fr
  24. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model.
    Authors: Mercurio L, Ajmone-Cat M, Cecchetti S, Ricci A, Bozzuto G, Molinari A, Manni I, Pollo B, Scala S, Carpinelli G, Minghetti L
    J Exp Clin Cancer Res, 2016-03-25;35(0):55.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  25. Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression
    Authors: CJ Coke, KA Scarlett, MA Chetram, KJ Jones, BJ Sandifer, AS Davis, AI Marcus, CV Hinton
    J. Biol. Chem., 2016-02-03;291(19):9991-10005.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  26. Identification and Characterization of CXCR4-Positive Gastric Cancer Stem Cells.
    Authors: Fujita T, Chiwaki F, Takahashi R, Aoyagi K, Yanagihara K, Nishimura T, Tamaoki M, Komatsu M, Komatsuzaki R, Matsusaki K, Ichikawa H, Sakamoto H, Yamada Y, Fukagawa T, Katai H, Konno H, Ochiya T, Yoshida T, Sasaki H
    PLoS ONE, 2015-06-25;10(6):e0130808.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  27. The long pentraxin PTX3 promotes fibrocyte differentiation.
    Authors: Pilling D, Cox N, Vakil V, Verbeek J, Gomer R
    PLoS ONE, 2015-03-16;10(3):e0119709.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC-Fr
  28. CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro.
    Authors: Hu, Weidong, Liu, Yue, Zhou, Wenhui, Si, Lianlian, Ren, Liang
    PLoS ONE, 2014-06-04;9(6):e99056.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-P
  29. Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer.
    Authors: Hartmann N, Giese N, Giese T, Poschke I, Offringa R, Werner J, Ryschich E
    Clin Cancer Res, 2014-04-24;20(13):3422-33.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  30. Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms.
    Authors: Jarajapu Y, Hazra S, Segal M, Li Calzi S, Jadhao C, Qian K, Mitter S, Raizada M, Boulton M, Grant M
    PLoS ONE, 2014-04-08;9(4):e93965.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  31. An important role of the SDF-1/CXCR4 axis in chronic skin inflammation.
    Authors: Zgraggen, Silvana, Huggenberger, Reto, Kerl, Katrin, Detmar, Michael
    PLoS ONE, 2014-04-02;9(4):e93665.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  32. Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node.
    Authors: Yin X, Johns S, Kim D, Mikulski Z, Salanga C, Handel T, Macal M, Zuniga E, Fuster M
    J Immunol, 2014-02-03;192(5):2133-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Functional Assay
  33. PCaAnalyser: a 2D-image analysis based module for effective determination of prostate cancer progression in 3D culture.
    Authors: Hoque, Md Tamji, Windus, Louisa C, Lovitt, Carrie J, Avery, Vicky M
    PLoS ONE, 2013-11-20;8(11):e79865.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  34. Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice.
    Authors: Brennecke P, Arlt M, Muff R, Campanile C, Gvozdenovic A, Husmann K, Holzwarth N, Cameroni E, Ehrensperger F, Thelen M, Born W, Fuchs B
    PLoS ONE, 2013-09-10;8(9):e74045.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  35. CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis.
    Authors: Gassenmaier M, Chen D, Buchner A, Henkel L, Schiemann M, Mack B, Schendel D, Zimmermann W, Pohla H
    Stem Cells, 2013-08-01;31(8):1467-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC-P
  36. Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070.
    Authors: O'Boyle, G, Swidenbank, I, Marshall, H, Barker, C E, Armstrong, J, White, S A, Fricker, S P, Plummer, R, Wright, M, Lovat, P E
    Br J Cancer, 2013-03-28;108(8):1634-40.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  37. The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma.
    Authors: Zhang, Lin, Ye, Shu-Biao, Ma, Gang, Tang, Xiao-Fen, Chen, Shi-Ping, He, Jia, Liu, Wan-Li, Xie, Dan, Zeng, Yi-Xin, Li, Jiang
    J Transl Med, 2013-03-08;11(0):60.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  38. The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer.
    Authors: Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Tacheuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S
    Clin. Cancer Res., 2011-04-11;17(11):3619-30.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  39. Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention.
    Authors: Franciszkiewicz K, Le Floc'h A, Jalil A, Vigant F, Robert T, Vergnon I, Mackiewicz A, Benihoud K, Validire P, Chouaib S, Combadiere C, Mami-Chouaib F
    Cancer Res., 2009-07-28;69(15):6249-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  40. Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer.
    Authors: Pfeiffer M, Hartmann TN, Leick M, Catusse J, Schmitt-Graeff A, Burger M
    Br. J. Cancer, 2009-05-19;100(12):1949-56.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  41. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
    Authors: Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P
    Dev. Biol., 2009-04-07;330(2):286-304.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  42. Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents.
    Authors: Gilbert DC, Chandler I, McIntyre A, Goddard NC, Gabe R, Huddart RA, Shipley J
    J. Pathol., 2009-01-01;217(1):94-102.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-P
  43. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells.
    Authors: Williams CK, Segarra M, Sierra Mde L, Sainson RC, Tosato G, Harris AL
    Cancer Res., 2008-03-15;68(6):1889-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  44. Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts.
    Authors: Tait LR, Pauley RJ, Santner SJ, Heppner GH, Heng HH, Rak JW, Miller FR
    Int. J. Cancer, 2007-05-15;120(10):2127-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  45. Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
    Authors: Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
    J. Immunol., 2006-05-15;176(10):5735-9.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  46. Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF.
    Authors: Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H
    Cardiovasc. Res., 2006-05-09;71(3):455-65.
    Species: Rabbit
    Sample Types: Whole Tissue
    Applications: IHC-P
  47. Human melanoma metastases express functional CXCR4.
    Authors: Scala S, Giuliano P, Ascierto PA, Ierano C, Franco R, Napolitano M, Ottaiano A, Lombardi ML, Luongo M, Simeone E, Castiglia D, Mauro F, De Michele I, Calemma R, Botti G, Caraco C, Nicoletti G, Satriano RA, Castello G
    Clin. Cancer Res., 2006-04-15;12(8):2427-33.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-Fr, IHC-P
  48. Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis.
    Authors: Haringman JJ, Smeets TJ, Reinders-Blankert P
    Ann. Rheum. Dis., 2005-08-17;65(3):294-300.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  49. Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus.
    Authors: Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bunemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B
    Arthritis Rheum., 2005-05-01;52(5):1504-16.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  50. Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone.
    Authors: Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY
    J. Orthop. Res., 2005-01-01;23(1):203-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  51. CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer.
    Authors: Mori T, Doi R, Koizumi M, Toyoda E, Ito D, Kami K, Masui T, Fujimoto K, Tamamura H, Hiramatsu K, Fujii N, Imamura M
    Mol. Cancer Ther., 2004-01-01;3(1):29-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  52. Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells.
    Authors: Zhang Y, Foudi A, Geay JF, Berthebaud M, Buet D, Jarrier P, Jalil A, Vainchenker W, Louache F
    Stem Cells, 2004-01-01;22(6):1015-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  53. CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.
    Authors: Cardones AR, Murakami T, Hwang ST
    Cancer Res., 2003-10-15;63(20):6751-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  54. CXCR4 function requires membrane cholesterol: implications for HIV infection.
    Authors: Nguyen DH, Taub D
    J. Immunol., 2002-04-15;168(8):4121-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, Neutralization
  55. Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire.
    Authors: Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, Wu L, Butcher E
    J Immunol, 2001-06-01;166(11):6477-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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Human CXCR4 Antibody
By Anonymous on 08/03/2021
Application: IHC Sample Tested: Ductal carcinoma,Tumor tissue Species: Human
Immunohistochemistry Human CXCR4 Antibody MAB172
Human CXCR4 Antibody
By Anonymous on 12/07/2020
Application: MiAr Sample Tested: EDTA Plasma Species: Human

Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma

Microarray Human CXCR4 Antibody MAB172
Human CXCR4 Antibody
By Anonymous on 11/16/2018
Sample Tested: Ramos human Burkitt's lymphoma cell line,SUDHL-6 Species: Human

Cell line stained with human CXCR4 for 45 min and secondary antibody anti-mouse FITC for 45min & Isotype control and unstained cell used in experiment

Human CXCR4 Antibody MAB172
Human CXCR4 Antibody
By Anonymous on 03/15/2018
Application: Flow Sample Tested: Human cell line Species: Human
Flow Cytometry Human CXCR4 Antibody MAB172