Human CXCR4 PE-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CXCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CXCR4 PE-conjugated Monoclonal Antibody (Catalog # FAB173P) and Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody (Catalog # FAB4867A). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 degreesC as supplied.
Background: CXCR4
CXCR4 is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells.
Product Datasheets
Citations for Human CXCR4 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
10
Citations: Showing 1 - 10
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Differential B-Cell Receptor Signaling Requirement for Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells
Authors: L Sadeghi, G Arvidsson, M Merrien, A M Wasik, A Görgens, CIE Smith, B Sander, AP Wright
Cancers (Basel), 2020-05-02;12(5):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
A human immunodeficiency syndrome caused by mutations in CARMIL2
Authors: T Schober, T Magg, M Laschinger, M Rohlfs, ND Linhares, J Puchalka, T Weisser, K Fehlner, J Mautner, C Walz, K Hussein, G Jaeger, B Kammer, I Schmid, M Bahia, SD Pena, U Behrends, BH Belohradsk, C Klein, F Hauck
Nat Commun, 2017-01-23;8(0):14209.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation.
Authors: Buckner, Clarisa, Moir, Susan, Kardava, Lela, Ho, Jason, Santich, Brian H, Kim, Leo Jin, Funk, Emily K, Nelson, Amy K, Winckler, Britanny, Chairez, Cheryl L, Theobald-Whiting, Narda L, Anaya-O'Brien, Sandra, Alimchandani, Meghna, Quezado, Martha M, Yao, Michael, Kovacs, Joseph A, Chun, Tae-Wook, Fauci, Anthony, Malech, Harry L, De Ravin, Suk See
J Allergy Clin Immunol, 2013-12-25;133(6):1676-85.e5.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells.
Authors: Liu, Che, Pham, Kien, Luo, Defang, Reynolds, Brent A, Hothi, Parvinde, Foltz, Gregory, Harrison, Jeffrey
PLoS ONE, 2013-03-21;8(3):e59750.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
Authors: Badr G, Lefevre EA, Mohany M
PLoS ONE, 2011-09-01;6(9):e23741.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
Authors: Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W
J. Immunol., 2011-06-10;187(2):748-59.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Human melanoma metastases express functional CXCR4.
Authors: Scala S, Giuliano P, Ascierto PA, Ierano C, Franco R, Napolitano M, Ottaiano A, Lombardi ML, Luongo M, Simeone E, Castiglia D, Mauro F, De Michele I, Calemma R, Botti G, Caraco C, Nicoletti G, Satriano RA, Castello G
Clin. Cancer Res., 2006-04-15;12(8):2427-33.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.
Authors: Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D
FEBS Lett., 2003-07-10;546(2):300-6.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
J. Leukoc. Biol., 2003-05-01;73(5):584-90.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo.
Authors: de Lavareille A, Roufosse F, Schandene L, Stordeur P, Cogan E, Goldman M
Eur. J. Immunol., 2001-04-01;31(4):1037-46.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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We use CXCR4 to test the % positive definitive endoderm made from human induced pluripotent stem cells.
