Human Endocan/ESM-1 Biotinylated Antibody Summary
Trp20-Arg184
Accession # Q9NQ30
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Endocan/ESM-1
Endocan, also known as endothelial-cell specific molecule-1 (ESM-1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung (1). Endocan expression has also been detected in different epithelia and in adipocytes (2, 3). The expression of endocan is up‑regulated by TNF alpha, IL-1 beta or lipopolysaccharide and down-regulated by IFN-gamma (1). The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues (1). The DS chain is covalently attached to serine 137 (4). Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen-1, LFA-1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM-1 and reducing LFA-1-mediated leukocyte activation (5). Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity (3, 6). Genetically engineered cells overexpressing endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo (3, 6). Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported (2, 6).
- Lassalle, P. et al. (1996) J. Biol. Chem. 271:20458.
- Bechard, D. et al. (2000) J. Vasc. Res. 37:417.
- Wellner, M. et al. (2003) Horm. Metab. Res. 35:217.
- Bechard, D. et al. (2001) J. Biol. Chem. 276:48341.
- Bechard, D. et al. (2001) J. Immunol. 167:3099
- Scherpereel, A. et al. (2003) Cancer Res. 63:6084.
Product Datasheets
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Human Endocan/ESM-1 Biotinylated Antibody
There are currently no reviews for this product. Be the first to review Human Endocan/ESM-1 Biotinylated Antibody and earn rewards!
Have you used Human Endocan/ESM-1 Biotinylated Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image