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Human FGF-17 Antibody

Catalog #: MAB319
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB319
MAB319-SP
FGF‑17 in Human Kidney.
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Citations (2)
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Human FGF-17 Antibody Summary

Species Reactivity
Human
Specificity
Detects human FGF-17 in direct ELISAs and Western blots. In direct ELISA, approximately 7% cross-reactivity with recombinant human (rh) FGF-5 is observed and no cross-reactivity with rhFGF-acidic, rhFGF-basic, rhFGF-4, rhFGF-6, rhFGF-7, rhFGF8b, rhFGF-9, rhFGF-10, rhFGF-17, rhFGF-18, rhFGF-19, recombinant mouse (rm) FGF-8b, rmFGF-8c and rmFGF-15 is observed.
Source
Monoclonal Mouse IgG2B Clone # 121630
Purification
Protein A or G purified from ascites
Immunogen
E. coli-derived recombinant human FGF-17
Thr23-Thr216
Accession # O60258
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human FGF‑17 (Catalog # 319-FG)
Immunohistochemistry
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry FGF‑17 antibody in Human Kidney by Immunohistochemistry (IHC-P). View Larger

FGF‑17 in Human Kidney. FGF‑17 was detected in immersion fixed paraffin-embedded sections of human kidney using Human FGF‑17 Monoclonal Antibody (Catalog # MAB319) at 8 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific labeling was localized to the basement membrane supporting epithelial cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: FGF-17

Fibroblast growth factors (FGFs) play multiple biological functions including angiogenesis, mitogenesis, cellular differentiation and wound repairing. All members of the FGF family have a conserved approximately 120 amino acid core with 30‑70% identity. Among FGF family members, FGF-17 is most similar to FGF-8 (60% sequence identity) and FGF-18 (50% sequence identity). The mRNA of FGF-17 was found in midgestation of embryo and multiple adult tissues, and is preferentially expressed in specific sites, such as embryonic brain, developing skeleton and arteries. Human FGF‑17 shares 98.6% amino acid (aa) sequence identity with mouse FGF‑17. Rat FGF‑17 shares 100% aa sequence identity with mouse FGF‑17.

References
  1. Hoshikawa, M. et al. (1998) Biochem. Biophys. Res. Commun. 244:187.
  2. Xu, J. et al. (1999) Mech. Dev. 83:165.
Long Name
Fibroblast Growth Factor 17
Entrez Gene IDs
8822 (Human); 14171 (Mouse)
Alternate Names
FGF-13; FGF17; FGF-17; fibroblast growth factor 17

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Citations for Human FGF-17 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Klotho Coreceptors Inhibit Signaling by Paracrine Fibroblast Growth Factor 8 Subfamily Ligands
    Authors: Regina Goetz, Mutsuko Ohnishi, Xunshan Ding, Hiroshi Kurosu, Lei Wang, Junko Akiyoshi et al.
    Molecular and Cellular Biology
  2. Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.
    Authors: Artavanis-Tsakonas K, Eleme K, McQueen KL, Cheng NW, Parham P, Davis DM, Riley EM
    J. Immunol., 2003-11-15;171(10):5396-405.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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