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Human FoxP1 Antibody

Catalog #: AF4534
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF4534
AF4534-SP
Detection of Human FoxP1 by Western Blot.
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Citations (7)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human FoxP1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human FoxP1 in Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human FoxP1
Leu231-Gly420
Accession # Q9H334
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Purity
Immunogen affinity purified

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human FoxP1 antibody by Western Blot. View Larger

Detection of Human FoxP1 by Western Blot. Western blot shows lysates of Daudi human Burkitt's lymphoma cell line. Gels were loaded with 30 µg of whole cell lysate (WCL), 20 µg of cytoplasmic (Cyto), and 10 µg of nuclear extracts (Nuc). PVDF membrane was probed with 1 µg/mL Goat Anti-Human FoxP1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4534) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band for FoxP1 was detected at approximately 82 - 90 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: FoxP1

Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors. FoxP1 has been implicated in cardiac, lung, and lymphocyte development. FoxP1 knock out mice die at embryonic day 14.5 due to heart valve and outflow tract abnormalities. FoxP1 contains both a DNA binding domain as well as protein-protein interaction domains. FoxP1 can homo or heterodimeize with FoxP2 and FoxP4, with dimerization necessary for DNA binding. FoxP1 shows both oncogenic and tumor suppressive characteristics. Overexpression in lymphomas leads to poor prognosis, whereas, loss of FoxP1 in breast cancer also implicates a poor prognosis.

Long Name
Forkhead Box P1
Entrez Gene IDs
27086 (Human); 108655 (Mouse); 297480 (Rat)
Alternate Names
FLJ23741; fork head-related protein like B; forkhead box P1; forkhead box protein P1; FoxP1; glutamine-rich factor 1; hFKH1B; HSPC215; MGC12942; MGC88572; MGC99551; QRF1; QRF112CC4

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Citations for Human FoxP1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons
    Authors: ES Liau, S Jin, YC Chen, WS Liu, M Calon, S Nedelec, Q Nie, JA Chen
    Oncogene, 2023-01-03;14(1):46.
    Species: Mouse
    Sample Types: Embryos
    Applications: IHC
  2. Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits
    Authors: M Toch, A Harris, O Schakman, E Kondratska, JL Boulland, N Dauguet, S Debrulle, C Baudouin, M Hidalgo-Fi, A Gow, JC Glover, F Tissir, F Clotman
    Sci Rep, 2020-01-22;10(1):996.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development
    Authors: KU Kabayiza, G Masgutova, A Harris, V Rucchin, B Jacob, F Clotman
    Front Mol Neurosci, 2017-05-26;10(0):157.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  4. The role of Sema3-Npn-1 signaling during diaphragm innervation and muscle development
    J Cell Sci, 2016-07-27;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  5. Fasciculation and Guidance of Spinal Motor Axons in the Absence of FGFR2 Signaling.
    Authors: Huettl RE, Haehl T, Huber AB
    PLoS ONE, 2012-07-17;7(7):e41095.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  6. Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb.
    Authors: Huettl RE, Soellner H, Bianchi E, Novitch BG, Huber AB
    PLoS Biol., 2011-02-22;9(2):e1001020.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development.
    Neuroscience, 2009-10-02;165(1):116-29.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr

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