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Human GDF-15 ELISA Kit - Quantikine

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Human GDF-15 Quantikine ELISA Kit Linearity Competitor Comparison
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Summary Sample Values Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Human GDF-15 Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
3.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (50 uL), Serum (13 uL), EDTA Plasma (13 uL), Heparin Plasma (13 uL), Urine (10 uL)
Sensitivity
4.39 pg/mL
Assay Range
23.4 - 1,500 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine)
Specificity
Natural and recombinant human GDF-15
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
Interference
No significant interference observed with available related molecules.

Sample Values

Sample TypeMean (pg/mL)Range (pg/mL)
Serum (n=35)565337-1060
EDTA Plasma (n=35)534289-1096
Heparin Plasma (n=35)507278-1064
Sample TypeMean (ng/mL)Range (ng/mL)
Urine (n=15)5.711.00-20.1

Product Summary

The Quantikine Human GDF-15 immunoassay is a 3.5 hour solid phase ELISA designed to measure GDF-15 in cell culture supernates, serum, plasma, and urine. It contains CHO cell-expressed recombinant human GDF-15 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural GDF-15 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values of naturally occurring GDF-15.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean (pg/mL) 238 456 886 225 442 900
Standard Deviation 4.27 9.86 25 13.4 20.6 50.5
CV% 1.8 2.2 2.8 6 4.7 5.6

Recovery

The recovery of GDF-15 spiked to levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=4) 100 94-106
EDTA Plasma (n=4) 97 85-108
Heparin Plasma (n=4) 96 86-108
Serum (n=4) 98 88-107
Urine (n=4) 102 88-108

Linearity

To assess the linearity of the assay, samples containing and/or spiked with high concentrations of GDF-15 were serially diluted with Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human GDF-15 ELISA Linearity

Scientific Data

N/A Human GDF-15 Quantikine ELISA Kit Linearity Competitor Comparison View Larger

Human GDF-15 Quantikine ELISA Kit Linearity Competitor Comparison

N/A Human GDF-15 Quantikine ELISA Kit Recovery Competitor Comparison View Larger

Human GDF-15 Quantikine ELISA Kit Recovery Competitor Comparison

N/A Human GDF-15 ELISA Standard Curve View Larger

Human GDF-15 ELISA Standard Curve

Product Datasheets

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: GDF-15

Growth/differentiation factors (GDF-1 to GDF-15) are members of the BMP family of TGF-beta superfamily proteins. They are produced as inactive preproproteins which are then cleaved and assembled into active secreted homodimers. GDF dimers are disulfide-linked with the exception of GDF-3 and -9. GDF proteins are important during embryonic development, particularly in the skeletal, nervous, and muscular systems.

Long Name:
Growth Differentiation Factor 15
Entrez Gene IDs:
9518 (Human); 23886 (Mouse); 29455 (Rat)
Alternate Names:
GDF15; GDF-15; growth differentiation factor 15; growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; MIC-1NSAID-activated gene 1 protein; MIC1Prostate differentiation factor; NAG-1; NAG-1NSAID-regulated gene 1 protein; NSAID (nonsteroidal inflammatory drug)-activated protein 1; PDF; PDFGDF-15; PLAB; PLABNRG-1; Placental bone morphogenetic protein; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
    3. 100 µL Assay Diluent
  3.   Add 100 µL of Assay Diluent to each well.
    4. 50 µL Standard, Control, or Sample
  4.   Add 50 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours on a horizontal orbital microplate shaker.
  5.   Aspirate each well and wash, repeating the process 3 times for a total of 4 washes.
    6. 200 µL Conjugate
  6.   Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 1 hour on the shaker.
  7.   Aspirate and wash 4 times.
    8. 200 µL Substrate Solution
  8.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes on the benchtop. PROTECT FROM LIGHT.
    9. 50 µL Stop Solution
  9.   Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Human GDF-15 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

86 Citations: Showing 1 - 10
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  1. Skin advanced glycation end-products as indicators of the metabolic profile in diabetes mellitus: correlations with glycemic control, liver phenotypes and metabolic biomarkers
    Authors: Christidis, G;Küppers, F;Karatayli, SC;Karatayli, E;Weber, SN;Lammert, F;Krawczyk, M;
    BMC endocrine disorders
    Species: Human
    Sample Types: Serum
  2. Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome
    Authors: Walitt, B;Singh, K;LaMunion, SR;Hallett, M;Jacobson, S;Chen, K;Enose-Akahata, Y;Apps, R;Barb, JJ;Bedard, P;Brychta, RJ;Buckley, AW;Burbelo, PD;Calco, B;Cathay, B;Chen, L;Chigurupati, S;Chen, J;Cheung, F;Chin, LMK;Coleman, BW;Courville, AB;Deming, MS;Drinkard, B;Feng, LR;Ferrucci, L;Gabel, SA;Gavin, A;Goldstein, DS;Hassanzadeh, S;Horan, SC;Horovitz, SG;Johnson, KR;Govan, AJ;Knutson, KM;Kreskow, JD;Levin, M;Lyons, JJ;Madian, N;Malik, N;Mammen, AL;McCulloch, JA;McGurrin, PM;Milner, JD;Moaddel, R;Mueller, GA;Mukherjee, A;Muñoz-Braceras, S;Norato, G;Pak, K;Pinal-Fernandez, I;Popa, T;Reoma, LB;Sack, MN;Safavi, F;Saligan, LN;Sellers, BA;Sinclair, S;Smith, B;Snow, J;Solin, S;Stussman, BJ;Trinchieri, G;Turner, SA;Vetter, CS;Vial, F;Vizioli, C;Williams, A;Yang, SB;Center for Human Immunology, Autoimmunity, and Inflammation (CHI) Consortium, ;Nath, A;
    Nature communications
    Species: Human hepegivirus
    Sample Types: Plasma
  3. Changes of biomarkers for erythropoiesis, iron metabolism, and FGF23 by supplementation with roxadustat in patients on hemodialysis
    Authors: S Yoshida, T Saito, K Shibagaki, K Hirao, T Yuza, N Tomosugi, H Honda
    Scientific Reports, 2023-02-23;13(1):3181.
    Species: Human
    Sample Types: Serum
  4. GDF15 Promotes Cell Growth, Migration, and Invasion in Gastric Cancer by Inducing STAT3 Activation
    Authors: M Joo, D Kim, MW Lee, HJ Lee, JM Kim
    International Journal of Molecular Sciences, 2023-02-02;24(3):.
    Species: Human
    Sample Types: Serum
  5. Growth Differentiation Factor-15 Predicts Mortality and Heart Failure Exacerbation But Not Ventricular Arrhythmias in Patients With Cardiomyopathy
    Authors: MS Binder, LR Yanek, W Yang, B Butcher, S Norgard, JE Marine, A Kolandaive, J Chrispin, NS Fedarko, H Calkins, B O'Rourke, KC Wu, GF Tomaselli, AS Barth
    Journal of the American Heart Association, 2023-01-31;12(3):e8023.
    Species: Human
    Sample Types: Serum
  6. GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia
    Authors: JY Kim-Muller, L Song, B LaCarubba, E Pashos, X Li, A Rinaldi, S Joaquim, JC Stansfield, J Zhang, A Robertson, J Pang, A Opsahl, M Boucher, D Breen, K Hales, A Sheikh, Z Wu, BB Zhang
    Cell Reports, 2023-01-10;42(1):111947.
    Species: Human
    Sample Types: Plasma
  7. Evaluating Cardiotoxicity in Breast Cancer Patients Treated with HER2 Inhibitors: Could a Combination of Radionuclide Ventriculography and Cardiac Biomarkers Predict the Cardiac Impact?
    Authors: M Gherghe, AM Lazar, MD Mutuleanu, CI Bordea, S Ionescu, RI Mihaila, C Petroiu, AE Stanciu
    Cancers, 2022-12-29;15(1):.
    Species: Human
    Sample Types: Serum
  8. Effects of acute exercise and exercise training on plasma GDF15 concentrations and associations with appetite and cardiometabolic health in individuals with overweight or obesity - A secondary analysis of a randomized controlled trial
    Authors: JS Quist, AB Klein, K Færch, K Beaulieu, M Rosenkilde, AS Gram, A Sjödin, S Torekov, B Stallknech, C Clemmensen, MB Blond
    Appetite, 2022-12-21;182(0):106423.
    Species: Human
    Sample Types: Plasma
  9. Circulating biomarker correlates of left atrial size and myocardial extracellular volume fraction among persons living with and without HIV
    Authors: TE Peterson, C Landon, SA Haberlen, F Bhondoekha, MW Plankey, FJ Palella, DA Piggott, JB Margolick, TT Brown, WS Post, KC Wu
    BMC cardiovascular disorders, 2022-09-03;22(1):393.
    Species: Human
    Sample Types: Serum
  10. GDF-15 and sST-2 act as biomarkers of disease severity but not independent predictors in idiopathic membranous nephropathy
    Authors: L Wu, L Luo, L Zhou, N Li, X Qin
    International immunopharmacology, 2022-08-24;111(0):109150.
    Species: Human
    Sample Types: Serum
  11. Clinical usefulness and acceleratory effect of macrophage inhibitory cytokine-1 on biliary tract cancer: an experimental biomarker analysis
    Authors: M Sugimoto, R Suzuki, Y Nozawa, T Takagi, N Konno, H Asama, Y Sato, H Irie, J Nakamura, M Takasumi, M Hashimoto, T Kato, R Kobashi, O Suzuki, Y Hashimoto, T Hikichi, H Ohira
    Cancer Cell International, 2022-08-10;22(1):250.
    Species: Human
    Sample Types: Serum
  12. The circulating proteomic signature of alcohol-associated liver disease
    Authors: J Luther, AG Vannier, EA Schaefer, RP Goodman
    JCI Insight, 2022-07-22;7(14):.
    Species: Human
    Sample Types: Serum
  13. Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults
    Authors: H Kared, AS Wolf, A Alirezayla, A Ravussin, G Solum, TT Tran, F Lund-Johan, JT Vaage, LS Nissen-Mey, UC Nygaard, O Hungnes, AH Robertson, LM Næss, L Trogstad, P Magnus, LA Munthe, S Mjaaland
    Nature Communications, 2022-07-18;13(1):4165.
    Species: Human
    Sample Types: Plasma
  14. Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma
    Authors: V Ananthapad, TC Frost, KM Soroko, A Knott, BJ Magliozzi, PC Gokhale, VG Tirunagaru, RC Doebele, JA DeCaprio
    JCI Insight, 2022-07-08;7(13):.
    Species: Mouse
    Sample Types: Plasma
  15. Growth differentiation factor 15 as a novel diagnostic and therapeutic marker for autoimmune hepatitis
    Authors: T Arinaga-Hi, T Ide, J Akiba, H Suzuki, R Kuwahara, K Amano, T Kawaguchi, T Sano, E Inoue, H Koga, K Mitsuyama, Y Koga, T Torimura
    Scientific Reports, 2022-05-24;12(1):8759.
    Species: Human
    Sample Types: Serum
  16. Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation
    Authors: Y Wang, C Chen, J Chen, T Sang, H Peng, X Lin, Q Zhao, S Chen, T Eling, X Wang
    Redox Biology, 2022-04-27;52(0):102322.
    Species: Human
    Sample Types: Serum
  17. High serum concentrations of growth differentiation factor-15 and their association with Crohn's disease and a low skeletal muscle index
    Authors: H Yamamoto, F Takeshima, M Haraguchi, Y Akazawa, K Matsushima, M Kitayama, K Ogihara, M Tabuchi, K Hashiguchi, N Yamaguchi, H Miyaaki, H Kondo, K Nakao
    Scientific Reports, 2022-04-21;12(1):6591.
    Species: Human
    Sample Types: Serum
  18. Application of Mitochondrial and Oxidative Stress Biomarkers in the Evaluation of Neurocognitive Prognosis Following Acute Carbon Monoxide Poisoning
    Authors: YS Cha, JS Chang, H Kim, KS Park
    Metabolites, 2022-02-24;12(3):.
    Species: Human
    Sample Types: Serum
  19. Aging Aggravates Cachexia in Tumor-Bearing Mice
    Authors: J Geppert, AA Walth, R Terrón Exp, D Kaltenecke, P Morigny, J Machado, M Becker, E Simoes, JDCC Lima, C Daniel, M Berriel Di, S Herzig, M Seelaender, M Rohm
    Cancers, 2021-12-24;14(1):.
    Species: Human
    Sample Types: Plasma
  20. Serum levels of the cold stress hormones FGF21 and GDF-15 after cardiac arrest in infants and children enrolled in single center therapeutic hypothermia clinical trials
    Authors: JR Herrmann, EL Fink, A Fabio, AK Au, RP Berger, K Janesko-Fe, RSB Clark, PM Kochanek, TC Jackson
    Resuscitation, 2021-11-22;0(0):.
    Species: Human
    Sample Types: Serum
  21. Differences in the Biomarker Profile of De Novo Acute Heart Failure versus Decompensation of Chronic Heart Failure
    Authors: S Nawrocka-M, J Biegus, M Hurkacz, M Guzik, M Rosiek-Bie, EA Jankowska, P Ponikowski, R Zymli?ski
    Biomolecules, 2021-11-16;11(11):.
    Species: Human
    Sample Types: Plasma
  22. Time Course and Role of Exercise-Induced Cytokines in Muscle Damage and Repair After a Marathon Race
    Authors: CAZ de Sousa, APR Sierra, BS Martínez G, JFS Maciel, R Manoel, HV Barbeiro, HP de Souza, MF Cury-Boave
    Frontiers in Physiology, 2021-10-15;12(0):752144.
    Species: Human
    Sample Types: Plasma
  23. Megaloblastic anemia-related iron overload and erythroid regulators: a case report
    Authors: N Vallet, JB Delaye, M Ropert, A Foucault, N Ravalet, S Deriaz, T Chalopin, H Blasco, F Maillot, O Hérault, E Gyan
    Journal of medical case reports, 2021-09-20;15(1):463.
    Species: Human
    Sample Types: Serum
  24. GDF-15 Predicts In-Hospital Mortality of Critically Ill Patients with Acute Kidney Injury Requiring Continuous Renal Replacement Therapy: A Multicenter Prospective Study
    Authors: JH Lim, Y Jeon, JS Ahn, S Kim, DK Kim, JP Lee, DR Ryu, EY Seong, SY Ahn, SH Baek, HY Jung, JY Choi, SH Park, CD Kim, YL Kim, JH Cho
    Journal of Clinical Medicine, 2021-08-18;10(16):.
    Species: Human
    Sample Types: Plasma
  25. The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice
    Authors: P Lertpatipa, J Lee, I Kim, T Eling, SY Oh, JK Seong, SJ Baek
    Scientific Reports, 2021-07-22;11(1):15027.
    Species: Mouse
    Sample Types: Serum
  26. Pharmacokinetic-pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies
    Authors: S Bauer, GD Demetri, E Halilovic, R Dummer, C Meille, DSW Tan, N Guerreiro, A Jullion, S Ferretti, S Jeay, L Van Bree, F Hourcade-P, JU Wuerthner, C Fabre, PA Cassier
    British Journal of Cancer, 2021-06-17;0(0):.
    Species: Human
    Sample Types: Serum
  27. Quercetin Induces Anticancer Activity by Upregulating Pro-NAG-1/GDF15 in Differentiated Thyroid Cancer Cells
    Authors: Y Hong, J Lee, H Moon, CH Ryu, J Seok, YS Jung, J Ryu, SJ Baek
    Cancers, 2021-06-16;13(12):.
    Species: Human
    Sample Types: Plasma
  28. Preoperative Serum GDF-15, Endothelin-1 Levels, and Intraoperative Factors as Short-Term Operative Risks for Patients Undergoing Cardiovascular Surgery
    Authors: T Kato, T Nakajima, T Fukuda, I Shibasaki, T Hasegawa, K Ogata, H Ogawa, S Hirota, H Ohashi, S Saito, Y Takei, M Tezuka, M Seki, T Kuwata, M Sakuma, S Abe, S Toyoda, T Inoue, H Fukuda
    Journal of Clinical Medicine, 2021-05-02;10(9):.
    Species: Human
    Sample Types: Serum
  29. Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study
    Authors: RLI Crake, MR Strother, E Phillips, MP Doogue, M Zhang, CMA Frampton, BA Robinson, MJ Currie
    Scientific Reports, 2021-03-11;11(1):5648.
    Species: Human
    Sample Types: Serum
  30. Clinically inapparent right heart dysfunction is associated with reduced myofilament force development in coronary artery disease
    Authors: C Bening, VL Sales, K Alhussini, D Radakovic, RC Benitez, N Madrahimov, D Keller, R Leyh
    BMC cardiovascular disorders, 2021-03-05;21(1):125.
    Species: Human
    Sample Types: Serum
  31. GDF15 as a biomarker of ageing
    Authors: H Liu, Y Huang, Y Lyu, W Dai, Y Tong, Y Li
    Experimental gerontology, 2021-01-06;146(0):111228.
    Species: Human
    Sample Types: Serum
  32. Growth Differentiation Factor 15: A Biomarker with High Clinical Potential in the Evaluation of Kidney Transplant Candidates
    Authors: M de Cos Gom, A Benito Her, MT Garcia Unz, J Mazon Ruiz, C Lopez Del, JL Perez Cang, D San Segund, R Valero San, JC Ruiz San M, E Rodrigo Ca
    Journal of Clinical Medicine, 2020-12-20;9(12):.
    Species: Human
    Sample Types: Serum
  33. Anaesthesia and ICU sedation with sevoflurane do not reduce myocardial injury in patients undergoing cardiac surgery: A randomized prospective study
    Authors: PG Guinot, O Ellouze, S Grosjean, V Berthoud, T Constandac, M Radhouani, JB Anciaux, S Aho-Glele, MC Morgant, C Girard, M Nguyen, B Bouhemad
    Medicine, 2020-12-11;99(50):e23253.
    Species: Human
    Sample Types: Plasma
  34. Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5
    Authors: Y Oikawa, R Izumi, M Koide, Y Hagiwara, M Kanzaki, N Suzuki, K Kikuchi, T Matsuhashi, Y Akiyama, M Ichijo, S Watanabe, T Toyohara, T Suzuki, E Mishima, Y Akiyama, Y Ogata, C Suzuki, H Hayashi, EN Kodama, KI Hayashi, E Itoi, M Aoki, S Kure, T Abe
    PLoS ONE, 2020-12-02;15(12):e0231064.
    Species: Human
    Sample Types: Cell Culture Supernates
  35. Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes
    Authors: JO Chung, SY Park, DH Cho, DJ Chung, MY Chung
    Sci Rep, 2020-11-25;10(1):20568.
    Species: Human
    Sample Types: Plasma
  36. Upregulated GDF-15 expression facilitates pancreatic ductal adenocarcinoma progression through orphan receptor GFRAL
    Authors: Z Zhao, J Zhang, L Yin, J Yang, Y Zheng, M Zhang, B Ni, H Wang
    Aging (Albany NY), 2020-11-17;12(0):.
    Species: Human
    Sample Types: Serum
  37. Impact of Smoking Status on Growth Differentiation Factor 15 and Mortality in Patients With Suspected or Known Coronary Artery Disease: The ANOX Study
    Authors: H Wada, M Suzuki, M Matsuda, Y Ajiro, T Shinozaki, S Sakagami, K Yonezawa, M Shimizu, J Funada, T Takenaka, Y Morita, T Nakamura, K Fujimoto, H Matsubara, T Kato, T Unoki, D Takagi, K Wada, M Wada, M Iguchi, N Masunaga, M Ishii, H Yamakage, T Kusakabe, A Yasoda, A Shimatsu, K Kotani, N Satoh-Asah, M Abe, M Akao, K Hasegawa, ANOX Study
    J Am Heart Assoc, 2020-11-10;9(22):e018217.
    Species: Human
    Sample Types: Serum
  38. Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females
    Authors: H Yazawa, T Fukuda, H Kaneda, R Waku, M Sakuma, A Matsumoto, S Toyoda, S Abe, F Nakamura, T Inoue, T Nakajima
    Int J Cardiol Heart Vasc, 2020-10-21;31(0):100651.
    Species: Human
    Sample Types: Serum
  39. The Role of GDF15 in Regulating the Canonical Pathways of the Tumor Microenvironment in Wild-Type p53 Ovarian Tumor and Its Response to Chemotherapy
    Authors: DI Izaguirre, CW Ng, SY Kwan, EH Kun, YTM Tsang, DM Gershenson, KK Wong
    Cancers (Basel), 2020-10-19;12(10):.
    Species: Mouse
    Sample Types: Serum
  40. Growth differentiation factor-15 as a biomarker for sarcopenia in aging humans and mice
    Authors: H Kim, KM Kim, MJ Kang, S Lim
    Exp Gerontol, 2020-10-16;142(0):111115.
    Species: Human
    Sample Types: Serum
  41. Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients
    Authors: MA Hannappe, L Arnould, A Méloux, B Mouhat, F Bichat, M Zeller, Y Cottin, C Binquet, C Vergely, C Creuzot-Ga, C Guenancia
    Sci Rep, 2020-10-07;10(1):16718.
    Species: Human
    Sample Types: Serum
  42. The clinical potential of GDF15 as a "ready-to-feed indicator" for critically ill adults
    Authors: L Van Dyck, J Gunst, MP Casaer, B Peeters, I Derese, PJ Wouters, F de Zegher, I Vanhorebee, G Van den Be
    Crit Care, 2020-09-14;24(1):557.
    Species: Human
    Sample Types: Serum
  43. Association between GDF15, poverty and mortality in urban middle-aged African American and white adults
    Authors: DW Freeman, N Noren Hoot, Y Kim, NA Mode, N Ejiogu, AB Zonderman, MK Evans
    PLoS ONE, 2020-08-07;15(8):e0237059.
    Species: Human
    Sample Types: Serum
  44. Growth Differentiation Factor 15 is a potential biomarker of therapeutic response for TK2 deficient myopathy
    Authors: C Dominguez-, C Badosa, M Madruga-Ga, I Martí, C Paradas, C Ortez, J Diaz-Maner, A Berardo, J Alonso-Pér, S Trifunov, D Cuadras, SG Kalko, C Blázquez-B, Y Cámara, R Martí, F Mavillard, MA Martin, J Montoya, E Ruiz-Pesin, J Villarroya, R Montero, F Villarroya, R Artuch, M Hirano, A Nascimento, C Jimenez-Ma
    Sci Rep, 2020-06-22;10(1):10111.
    Species: Human
    Sample Types: Serum
  45. Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice
    Authors: DF De Jesus, K Orime, D Kaminska, T Kimura, G Basile, CH Wang, L Haertle, R Riemens, NK Brown, J Hu, V Männistö, AM Silva, E Dirice, YH Tseng, T Haaf, J Pihlajamäk, RN Kulkarni
    J. Clin. Invest., 2020-05-01;0(0):.
    Species: Human
    Sample Types: Plasma
  46. GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss
    Authors: T Borner, HS Wald, MY Ghidewon, B Zhang, Z Wu, BC De Jonghe, D Breen, HJ Grill
    Cell Rep, 2020-04-21;31(3):107543.
    Species: Rat
    Sample Types: Plasma
  47. Cardiac Remodeling Biomarkers as Potential Circulating Markers of Left Ventricular Hypertrophy in Heart Failure with Preserved Ejection Fraction
    Authors: VT Mitic, DR Stojanovic, MZ Deljanin I, MM Stojanovic, DB Petrovic, AM Ignjatovic, NZ Stefanovic, GM Kocic, VV Bojanic
    Tohoku J. Exp. Med., 2020-04-01;250(4):233-242.
    Species: Human
    Sample Types: Plasma
  48. Growth differentiation factor 15 as a useful biomarker of heart failure in young patients with unrepaired congenital heart disease of left to right shunt
    Authors: Y Kagiyama, S Yatsuga, M Kinoshita, Y Koteda, S Kishimoto, Y Koga, K Suda
    J Cardiol, 2019-12-26;0(0):.
    Species: Human
    Sample Types: Serum
  49. Association of Extracellular Vesicle Protein Cargo with Race and Clinical Markers of Mortality
    Authors: N Noren Hoot, MH McFarland, DW Freeman, NA Mode, N Ezike, AB Zonderman, MK Evans
    Sci Rep, 2019-11-26;9(1):17582.
    Species: Human
    Sample Types: Serum
  50. Growth Differentiation Factor-15 (GDF-15) is a Biomarker of Muscle Wasting and Renal Dysfunction in Preoperative Cardiovascular Surgery Patients
    Authors: T Nakajima, I Shibasaki, T Sawaguchi, A Haruyama, H Kaneda, T Nakajima, T Hasegawa, T Arikawa, S Obi, M Sakuma, H Ogawa, S Toyoda, F Nakamura, S Abe, H Fukuda, T Inoue
    J Clin Med, 2019-10-01;8(10):.
    Species: Human
    Sample Types: Serum
  51. Growth differentiation factor-15 predicts poor survival after cardiac arrest
    Authors: B Richter, T Uray, KA Krychtiuk, C Schriefl, M Lenz, A Nürnberger, SP Kastl, J Wojta, G Heinz, M Schwameis, WS Speidl
    Resuscitation, 2019-08-05;143(0):22-28.
    Species: Human
    Sample Types: Serum
  52. Apomorphine rescues reactive oxygen species-induced apoptosis of fibroblasts with mitochondrial disease
    Authors: A Miyauchi, T Kouga, EF Jimbo, T Matsuhashi, T Abe, T Yamagata, H Osaka
    Mitochondrion, 2019-07-26;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  53. Serum Hepcidin and GDF-15 levels as prognostic markers in urothelial carcinoma of the upper urinary tract and renal cell carcinoma
    Authors: L Traeger, I Ellermann, H Wiethoff, J Ihbe, I Gallitz, M Eveslage, R Moritz, E Herrmann, AJ Schrader, AU Steinbicke
    BMC Cancer, 2019-01-15;19(1):74.
    Species: Human
    Sample Types: Serum
  54. Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer
    Authors: H Engerud, K Hope, HF Berg, KE Fasmer, IL Tangen, IS Haldorsen, J Trovik, C Krakstad
    PLoS ONE, 2019-01-15;14(1):e0210585.
    Species: Human
    Sample Types: Plasma
  55. Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients
    Authors: CK Wu, MM Su, YF Wu, JJ Hwang, LY Lin
    J Clin Med, 2018-11-08;7(11):.
    Species: Human
    Sample Types: Plasma
  56. Dose and schedule determine distinct molecular mechanisms underlying the efficacy of the p53-MDM2 inhibitor HDM201
    Authors: S Jeay, S Ferretti, P Holzer, J Fuchs, EA Chapeau, M Wartmann, D Sterker, V Romanet, M Murakami, G Kerr, EY Durand, S Gaulis, M Cortes-Cro, S Ruetz, TM Stachyra, J Kallen, P Furet, J Wuerthner, N Guerreiro, E Halilovic, A Jullion, A Kauffmann, E Kuriakose, M Wiesmann, MR Jensen, F Hofmann, WR Sellers
    Cancer Res., 2018-08-22;0(0):.
    Species: Human
    Sample Types: Plasma
  57. Growth differentiation factor-15 levels and the risk of contrast induced nephropathy in patients with acute myocardial infarction undergoing percutaneous coronary intervention: A retrospective observation study
    Authors: L Sun, X Zhou, J Jiang, X Zang, X Chen, H Li, H Cao, Q Wang
    PLoS ONE, 2018-05-23;13(5):e0197609.
    Species: Human
    Sample Types: Serum
  58. Plasma inflammatory cytokines and survival of pancreatic cancer patients
    Authors: A Babic, N Schnure, NP Neupane, MM Zaman, N Rifai, MW Welch, LK Brais, DA Rubinson, V Morales-Oy, C Yuan, S Zhang, EM Poole, BM Wolpin, MH Kulke, DA Barbie, K Wong, CS Fuchs, K Ng
    Clin Transl Gastroenterol, 2018-04-25;9(4):145.
    Species: Human
    Sample Types: Plasma
  59. GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2
    Authors: S Li, YM Ma, PS Zheng, P Zhang
    J. Exp. Clin. Cancer Res., 2018-04-10;37(1):80.
    Species: Human
    Sample Types: Cell Culture Supernates
  60. Association of Biomarker Clusters With Cardiac Phenotypes and Mortality in Patients With HIV Infection
    Authors: R Scherzer, SJ Shah, E Secemsky, J Butler, C Grunfeld, MG Shlipak, PY Hsue
    Circ Heart Fail, 2018-04-01;11(4):e004312.
    Species: Human
    Sample Types: Serum
  61. Growth differentiation factor-15 levels and the risk of contrast induced acute kidney injury in acute myocardial infarction patients treated invasively: A propensity-score match analysis
    Authors: L Sun, X Zhou, J Jiang, X Zang, X Chen, H Li, H Cao, Q Wang
    PLoS ONE, 2018-03-12;13(3):e0194152.
    Species: Human
    Sample Types: Serum
  62. Growth Differentiation Factor-15 as a Predictor of Idiopathic Membranous Nephropathy Progression: A Retrospective Study
    Authors: YR Ham, CH Song, HJ Bae, JY Jeong, MK Yeo, DE Choi, KR Na, KW Lee
    Dis. Markers, 2018-02-22;2018(0):1463940.
    Species: Human
    Sample Types: Serum
  63. GDF-15 is a better complimentary marker for risk stratification of arrhythmic death in non-ischaemic, dilated cardiomyopathy than soluble ST2
    Authors: S Stojkovic, A Kaider, L Koller, M Brekalo, J Wojta, A Diedrich, S Demyanets, T Pezawas
    J. Cell. Mol. Med., 2018-02-04;0(0):.
    Species: Human
    Sample Types: Plasma
  64. Exercise increases circulating GDF15 in humans
    Authors: M Kleinert, C Clemmensen, KA Sjøberg, CS Carl, JF Jeppesen, JFP Wojtaszews, B Kiens, EA Richter
    Mol Metab, 2018-01-17;0(0):.
    Species: Human
    Sample Types: Plasma
  65. Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis
    Authors: L Buendgens, E Yagmur, J Bruensing, U Herbers, C Baeck, C Trautwein, A Koch, F Tacke
    Dis. Markers, 2017-10-18;2017(0):5271203.
    Species: Human
    Sample Types: Serum
  66. NF-?B regulates GDF-15 to suppress macrophage surveillance during early tumor development
    Authors: NM Ratnam, JM Peterson, EE Talbert, KJ Ladner, PV Rajasekera, CR Schmidt, ME Dillhoff, BJ Swanson, E Haverick, RD Kladney, TM Williams, GW Leone, DJ Wang, DC Guttridge
    J. Clin. Invest., 2017-09-11;0(0):.
    Species: Human
    Sample Types: Plasma
  67. The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer
    Authors: M Sugimoto, T Takagi, N Konno, R Suzuki, H Asama, K Watanabe, J Nakamura, Y Waragai, H Kikuchi, M Takasumi, Y Sato, T Hikichi, H Ohira
    Sci Rep, 2017-08-23;7(1):9198.
    Species: Human
    Sample Types: Serum
  68. Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases
    Authors: T Matsuhashi, T Sato, SI Kanno, T Suzuki, A Matsuo, Y Oba, M Kikusato, E Ogasawara, T Kudo, K Suzuki, O Ohara, H Shimbo, F Nanto, H Yamaguchi, D Saigusa, Y Mukaiyama, A Watabe, K Kikuchi, H Shima, E Mishima, Y Akiyama, Y Oikawa, HO Hsin-Jung, Y Akiyama, C Suzuki, M Uematsu, M Ogata, N Kumagai, M Toyomizu, A Hozawa, N Mano, Y Owada, S Aiba, T Yanagisawa, Y Tomioka, S Kure, S Ito, K Nakada, KI Hayashi, H Osaka, T Abe
    EBioMedicine, 2017-05-13;0(0):.
    Species: Human
    Sample Types: Serum
  69. GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients
    Authors: N Ban, CJ Siegfried, JB Lin, YB Shui, J Sein, W Pita-Thoma, A Sene, A Santeford, M Gordon, R Lamb, Z Dong, SC Kelly, V Cavalli, J Yoshino, RS Apte
    JCI Insight, 2017-05-04;2(9):.
    Species: Human
    Sample Types: Aqueous Humor
  70. Antibody Array Revealed PRL-3 Affects Protein Phosphorylation and Cytokine Secretion
    Authors: Y Yang, S Lian, L Meng, L Qu, C Shou
    PLoS ONE, 2017-01-09;12(1):e0169665.
    Species: Human
    Sample Types: Cell Culture Supernates
  71. Growth differentiation factor 15 increases following oral glucose ingestion: effect of meal composition and obesity
    Authors: Marie Helene Schernthan
    Eur. J. Endocrinol, 2016-12-01;175(6):623-631.
    Species: Human
    Sample Types: Serum
  72. Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting
    Authors: Zhize Yuan
    Sci Rep, 2016-06-17;6(0):28221.
    Species: Human
    Sample Types: Plasma
  73. Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer.
    Authors: Mahon K, Lin H, Castillo L, Lee B, Lee-Ng M, Chatfield M, Chiam K, Breit S, Brown D, Molloy M, Marx G, Pavlakis N, Boyer M, Stockler M, Daly R, Henshall S, Horvath L
    Br J Cancer, 2015-03-31;112(8):1340-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  74. GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways.
    Authors: Urakawa, Naoki, Utsunomiya, Soken, Nishio, Mari, Shigeoka, Manabu, Takase, Nobuhisa, Arai, Noriaki, Kakeji, Yoshihir, Koma, Yu-Ichir, Yokozaki, Hiroshi
    Lab Invest, 2015-03-02;95(5):491-503.
    Species: Human
    Sample Types: Cell Culture Supernates
  75. Anti-tumoral effects of miR-3189-3p in glioblastoma.
    Authors: Jeansonne D, DeLuca M, Marrero L, Lassak A, Pacifici M, Wyczechowska D, Wilk A, Reiss K, Peruzzi F
    J Biol Chem, 2015-02-02;290(13):8067-80.
    Species: Human
    Sample Types: Cell Culture Supernates
  76. Growth differentiation factor-15 (GDF-15) levels are associated with cardiac and renal injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.
    Authors: Kahli A, Guenancia C, Zeller M, Grosjean S, Stamboul K, Rochette L, Girard C, Vergely C
    PLoS ONE, 2014-08-29;9(8):e105759.
    Species: Human
    Sample Types: Plasma
  77. A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease.
    Authors: Fujiwara, Tohru, Ikeda, Takashi, Nagasaka, Yuki, Okitsu, Yoko, Katsuoka, Yuna, Fukuhara, Noriko, Onishi, Yasushi, Ishizawa, Kenichi, Ichinohasama, Ryo, Tomosugi, Naohisa, Harigae, Hideo
    PLoS ONE, 2013-09-27;8(9):e75568.
    Species: Human
    Sample Types: Cell Culture Supernates
  78. Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells.
    Authors: Andre T, Meuleman N, Stamatopoulos B, De Bruyn C, Pieters K, Bron D, Lagneaux L
    PLoS ONE, 2013-03-21;8(3):e59756.
    Species: Human
    Sample Types: Cell Culture Supernates
  79. Bone marrow mesenchymal stem cells in patients with beta thalassemia major: molecular analysis with attenuated total reflection-Fourier transform infrared spectroscopy study as a novel method.
    Stem Cells Dev., 2012-02-15;21(11):2000-11.
    Species: Human
    Sample Types: Bone Marrow Fluid
  80. Regulation of hepcidin expression at high altitude.
    Authors: Talbot NP, Lakhal S, Smith TG, Privat C, Nickol AH, Rivera-Ch M, Leon-Velarde F, Dorrington KL, Mole DR, Robbins PA
    Blood, 2011-11-30;119(3):857-60.
    Species: Human
    Sample Types: Plasma
  81. Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes.
    Authors: Si Y, Liu X, Cheng M, Wang M, Gong Q, Yang Y, Wang T, Yang W
    PLoS ONE, 2011-05-23;6(5):e19967.
    Species: Human
    Sample Types: Serum
  82. Hypoxia potentiates glioma-mediated immunosuppression.
    Authors: Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W, Heimberger AB
    PLoS ONE, 2011-01-20;6(1):e16195.
    Species: Human
    Sample Types: Cell Culture Supernates
  83. The relationship between insulin resistance and the cardiovascular biomarker growth differentiation factor-15 in obese patients.
    Authors: Vila G, Riedl M, Anderwald C, Resl M, Handisurya A, Clodi M, Prager G, Ludvik B, Krebs M, Luger A
    Clin. Chem., 2010-12-16;57(2):309-16.
    Species: Human
    Sample Types: Plasma
  84. Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project.
    Authors: Piperno A, Galimberti S, Mariani R
    Blood, 2010-12-13;117(10):2953-9.
    Species: Human
    Sample Types: Serum
  85. Sensitive plasma protein analysis by microparticle-based proximity ligation assays.
    Authors: Darmanis S, Nong RY, Hammond M, Gu J, Alderborn A, Vanelid J, Siegbahn A, Gustafsdottir S, Ericsson O, Landegren U, Kamali-Moghaddam M
    Mol. Cell Proteomics, 2009-11-27;9(2):327-35.
    Species: Human
    Sample Types: Plasma
  86. Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease.
    Authors: Ashby DR, Gale DP, Busbridge M, Murphy KG, Duncan ND, Cairns TD, Taube DH, Bloom SR, Tam FW, Chapman RS, Maxwell PH, Choi P
    Kidney Int., 2009-02-11;75(9):976-81.
    Species: Human
    Sample Types: Plasma

FAQs

  1. Does the Human GDF-15 Quantikine ELISA Kit detect a specific GDF-15 variant?

    • The kit is designed to target wild-type Human GDF-15 protein  (accession #Q99988). However, we are aware of publications that cite the use of this kit for measurement of other GDF-15 variants.

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Human GDF-15 Quantikine ELISA Kit
By Anonymous on 03/14/2019
Sample Tested: Serum and Plasma
Human GDF-15 Quantikine ELISA Kit DGD150
Human GDF-15 Quantikine ELISA Kit
By Ruhul Choudhury on 01/22/2017
Sample Tested: extravillous trophoblasts conditioned medium

Used to measure GDF-15 concentration in first trimester extravillous trophoblasts.