Human GDNF Biotinylated Antibody Summary
Arg109-Ile211
Accession # P39905
Applications
Human GDNF Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: GDNF
Glial Cell Line-derived Neurotrophic Factor (GDNF) is a neurotrophic factor that has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Neuronal subpopulations that have been shown to be affected by GDNF include motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons.
Native GDNF, a disulfide-linked homodimeric glycoprotein, is a novel member of the TGF-beta superfamily. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells.
Product Datasheets
Citations for Human GDNF Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial
Authors: RH Baloh, JP Johnson, P Avalos, P Allred, S Svendsen, G Gowing, K Roxas, A Wu, B Donahue, S Osborne, G Lawless, B Shelley, K Wheeler, C Prina, D Fine, T Kendra-Rom, H Stokes, V Manoukian, A Muthukumar, L Garcia, MG Bañuelos, M Godoy, C Bresee, H Yu, D Drazin, L Ross, R Naruse, H Babu, EA Macklin, A Vo, A Elsayegh, W Tourtellot, M Maya, M Burford, F Diaz, CG Patil, RA Lewis, CN Svendsen
Nature Medicine, 2022-09-05;28(9):1813-1822.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Intravitreal Co-Administration of GDNF and CNTF Confers Synergistic and Long-Lasting Protection against Injury-Induced Cell Death of Retinal Ganglion Cells in Mice
Authors: S Dulz, M Bassal, K Flachsbart, K Riecken, B Fehse, S Schlichtin, S Bartsch, U Bartsch
Cells, 2020-09-11;9(9):.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons.
Authors: Elsworth JD, Redmond DE, Leranth C, Bjugstad KB, Sladek JR, Collier TJ, Foti SB, Samulski RJ, Vives KP, Roth RH
Exp. Neurol., 2008-02-15;211(1):252-8.
Species: Primate - Chlorocebus sabaeus (Green Monkey)
Sample Types: Whole Tissue
Applications: IHC-Fr -
Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease.
Authors: Sajadi A, Bensadoun JC, Schneider BL, Lo Bianco C, Aebischer P
Neurobiol. Dis., 2005-11-21;22(1):119-29.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P
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