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Human IL-11 Antibody

Catalog #: MAB218
9 Citations 2 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB218
MAB218-SP
Cell Proliferation Induced by IL‑11 and Neutralization by Human IL‑11 Antibody.
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Product Details
Citations (9)
FAQs
Supplemental Products
Reviews (2)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human IL-11 Antibody Summary

Species Reactivity
Human
Specificity
Detects human IL-11 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross-reactivity with recombinant mouse IL-11 is observed and no cross-reactivity with recombinant human (rh) IL-6, rhCNTF, rhLIF, rhOSM, rhCLC, or rhCT-1 is observed.
Source
Monoclonal Mouse IgG2A Clone # 22626
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human IL‑11
Pro22-Leu199
Accession # P20809
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human IL‑11 (Catalog # 218-IL)
Neutralization
Measured by its ability to neutralize IL‑11-induced proliferation in the T11 mouse plasmacytoma cell line. Nordan, R. P. et al. (1987) J. Immunol. 139:813. The Neutralization Dose (ND50) is typically ≤ 8 µg/mL in the presence of 1 ng/mL Recombinant Human IL‑11.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Neutralization Cell Proliferation Induced by IL‑11 and Neutralization by Human IL‑11 Antibody. View Larger

Cell Proliferation Induced by IL‑11 and Neutralization by Human IL‑11 Antibody. Recombinant Human IL-11 (Catalog # 218-IL) stimulates proliferation in the T11 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL-11 (1 ng/mL) is neutralized (green line) by increasing concen-trations of Mouse Anti-Human IL-11 Monoclonal Antibody (Catalog # MAB218). The ND50 is typically ≤ 8 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-11

Interleukin-11 (IL-11) is a pleiotropic cytokine produced by stromal cells. It binds to a dimeric receptor complex consisting of the IL-11 Ra chain and the gp130 chain shared by the receptors for the IL-6 cytokine family. IL-11 has multiple effects on hematopoietic cells and osteoblasts.

Long Name
Interleukin 11
Entrez Gene IDs
3589 (Human); 16156 (Mouse); 171040 (Rat); 102128313 (Cynomolgus Monkey)
Alternate Names
Adipogenesis inhibitory factor; AGIF; AGIFoprelvekin; IL11; IL-11; IL-11Oprelvekin; interleukin 11; interleukin-11; Oprelvekin

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Citations for Human IL-11 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

9 Citations: Showing 1 - 9
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  1. Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease
    Authors: AA Widjaja, S Viswanatha, SG Shekeran, E Adami, WW Lim, S Chothani, J Tan, JWT Goh, HM Chen, SY Lim, CM Boustany-K, J Hawkins, E Petretto, N Hübner, S Schafer, TM Coffman, SA Cook
    Nature Communications, 2022-12-05;13(1):7497.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  2. WNT/beta-Catenin Signaling Promotes TGF-beta-Mediated Activation of Human Cardiac Fibroblasts by Enhancing IL-11 Production
    Authors: E Dzia?o, M Czepiel, K Tkacz, M Siedlar, G Kania, P B?yszczuk
    International Journal of Molecular Sciences, 2021-09-17;22(18):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  3. DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression
    Authors: Z Chen, X Chen, R Xie, M Huang, W Dong, J Han, J Zhang, Q Zhou, H Li, J Huang, T Lin
    Mol. Ther., 2019-01-09;27(2):326-341.
    Species: Human
    Sample Types: Whole Cells
    Applications: Inhibition
  4. Upregulation of IL-11, an IL-6 Family Cytokine, Promotes Tumor Progression and Correlates with Poor Prognosis in Non-Small Cell Lung Cancer
    Authors: M Zhao, Y Liu, R Liu, J Qi, Y Hou, J Chang, L Ren
    Cell. Physiol. Biochem., 2018-03-10;45(6):2213-2224.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  5. Production and characterization of genetically modified human IL-11 variants
    Authors: Kouhei Tsumoto
    Biochim. Biophys. Acta, 2016-11-22;1861(2):205-217.
    Applications: Western Blot
  6. MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11.
    Authors: Zhou C, Ji J, Cai Q, Shi M, Chen X, Yu Y, Zhu Z, Zhang J
    BMC Cancer, 2015-05-02;15(0):343.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  7. IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI.
    Authors: Kim J, Kim M, Ham A, Brown K, Greene R, D'Agati V, Lee H
    J Am Soc Nephrol, 2013-06-27;24(10):1558-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  8. Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells.
    Authors: Onnis, Barbara, Fer, Nicole, Rapisarda, Annamari, Perez, Victor S, Melillo, Giovanni
    J Clin Invest, 2013-03-15;123(4):1615-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  9. MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.
    Authors: Bockhorn, Jessica, Dalton, Rachel, Nwachukwu, Chika, Huang, Simo, Prat, Aleix, Yee, Kathy, Chang, Ya-Fang, Huo, Dezheng, Wen, Yujia, Swanson, Kaitlin, Qiu, Tyler, Lu, Jun, Park, Seo Youn, Dolan, M Eileen, Perou, Charles, Olopade, Olufunmi, Clarke, Michael, Greene, Geoffrey, Liu, Huiping
    Nat Commun, 2013-01-01;4(0):1393.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization

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Human IL-11 Antibody
By Anonymous on 08/27/2021
Application: WB Sample Tested: HEK293 cells Species: Human
Western Blot Human IL-11 Antibody MAB218
Human IL-11 Antibody
By Anonymous on 05/26/2020
Application: Characterization by SEC. 98% monomer Sample Tested: Recombinant protein Species: Mouse
Other Human IL-11 Antibody MAB218